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IKBKG — IRS1

Pathways - manually collected, often from reviews:

• KEGG Adipocytokine signaling pathway: CHUK/IKBKB/IKBKG → IRS1/IRS2/IRS4 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of CHUK-IKBKG-IRS1-IKBKG-CHUK-IKBKG-IRS1-CHUK-IRS1 (in vivo) Gao et al., J Biol Chem 2002*

Text-mined interactions from Literome

Gao et al., J Biol Chem 2003 (Insulin Resistance) : Taken together, these data suggest that serine phosphorylation of IRS-1 in response to TNF-alpha is mediated , in part, by JNK and IKK
He et al., Mol Endocrinol 2006 (Insulin Resistance) : Tyrosine phosphorylation of IRS-1 was recovered only by the IKK inhibitor or JNK inhibitor, suggesting specific involvement of these two kinases
Nakamori et al., J Cell Biol 2006 : Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha induced serine307 phosphorylation of IRS-1 ... NEMO expression also enhanced TNF-alpha induced Ser307-IRS-1 phosphorylation and inhibited glucose uptake