Wajapeyee et al., J Biol Chem 2003
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Cell cycle arrest and apoptosis induction by activator protein 2alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 in AP-2alpha mediated growth inhibition
Melnikova et al., PloS one 2010
(Disease Progression...) :
Upregulation of AP-2alpha expression following CREB silencing increases endogenous p21 ( Waf1 ) and decreases MCAM/MUC18, both known to be downstream target genes of AP-2alpha involved in melanoma progression
Scibetta et al., Cell cycle (Georgetown, Tex.) 2010
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We further describe a non-tumourgenic breast epithelial cell line model to study the role of endogenous TFAP2A and p53 in the control of drug induced p21cip expression using ChIP ... Maximal expression of CDKN1A requires TFAP2A which binds to two regions of the promoter : the proximal region where the AP-2 site lies and upstream near the major p53 binding site