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CBL — CD28

Text-mined interactions from Literome

Zhang et al., J Immunol 2002 : In this report, we show that CD28 costimulation selectively induces greater ubiquitination and degradation of Cbl-b in wild-type T cells than CD3 stimulation alone, and TCR induced Cbl-b ubiquitination and degradation are significantly reduced in CD28-deficient T cells ... Our results demonstrate that CD28 costimulation regulates the threshold for T cell activation, at least in part, by promoting Cbl-b ubiquitination and degradation
Xu et al., Mech Ageing Dev 2004 : We show that young splenic T-lymphocytes reduced Cbl-b expression when stimulated with anti-CD3 and anti-CD28 antibodies, while in aged T-lymphocytes the CD28 dependent Cbl-b down-regulation did not occur
Li et al., J Immunol 2004 : These observations indicate that CD28 and CTLA-4 tightly regulate Cbl-b expression which is critical for establishing the threshold for T cell activation
Yang et al., Nat Immunol 2008 : Nedd4 ( -/- ) T cells contained more of the E3 ubiquitin ligase Cbl-b, and Nedd4 was required for polyubiquitination of Cbl-b induced by CD28 costimulation
Alcázar et al., Blood 2009 : CD28 enhances T-cell receptor signals and reduces expression of CBL ubiquitin ligases, which negatively control T-cell activation
Oh et al., Clin Exp Allergy 2011 (Pneumonia) : As an E3 ubiquitin ligase and a molecular adaptor, Cbl-b controls the activation threshold of the antigen receptor and negatively regulates CD28 costimulation, functioning as an intrinsic mediator of T cell anergy that maintains tolerance