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IFNG — PCNA
Text-mined interactions from Literome
Dey et al., J Cell Biochem 1999
:
To understand the antiproliferative signaling of IFNgamma, we studied the
effect of
IFNgamma on expression of c-Myc, Mad1, Max,
cyclin D1, and cyclin D2 genes in both a macrophage cell line and in primary bone marrow derived macrophages ( BMM ) in response to colony stimulating factor-1 (CSF-1)
Sibinga et al., J Biol Chem 1999
:
Interferon-gamma mediated inhibition of
cyclin A gene transcription is independent of individual cis acting elements in the cyclin A promoter ... We hypothesize that
IFN-gamma inhibits
cyclin A transcription by modifying co-activators or general transcription factors within the complex that drives transcription of the cyclin A gene
Dey et al., Biochim Biophys Acta 2000
:
Cell cycle independent
induction of D1 and D2 cyclin expression, but not
cyclin-Cdk complex formation or Rb phosphorylation, by
IFNgamma in macrophages
Ji et al., Chin Med J (Engl) 2001
:
IFN-gamma could significantly
inhibit the expression of
PCNA by intimal SMCs one week after denudation, when counting 200 intimal cells for PCNA positive reactions with an inhibitory rate of 88.50 % ( P < 0.001 )
Barten et al., Cell Prolif 2007
:
In group II, increased TRL-PK over time did not further inhibit expression of CD25, but
inhibited PCNA expression more on day 3, and IL-2 and
IFN-gamma expression was significantly higher on days 2 and 3 compared to PD effects of CsA ( P < 0.05 )