Amin et al., Am J Physiol Cell Physiol 2006
:
IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1 ... Our data indicate that IFN-gamma and TNF-alpha may repress the NHE3 promoter activity in C2BBe1 cells by PKA mediated phosphorylation of Sp1 and Sp3 transcription factors
Kiela et al., Gastroenterology 2009
(Gastrointestinal Hemorrhage) :
In mice, NHE3 deficiency leads to mild diarrhea, increased intestinal expression of interferon (IFN)-gamma , and distal colitis, suggesting its role in epithelial barrier homeostasis