We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to MTOR

MTOR — PML

Pathways - manually collected, often from reviews:

  • NCI Pathway Database mTOR signaling pathway: PML (PML) → mTORC1/PRAS40/DEPTOR/PML complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-PML) (modification, collaborate)
    Bernardi et al., Nature 2006
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database mTOR signaling pathway: PML (PML) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
    Bernardi et al., Nature 2006
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database mTOR signaling pathway: mTORC1/PRAS40/DEPTOR/PML complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-PML) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
    Bernardi et al., Nature 2006
    Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wang et al., Autophagy 2011 : In contrast, rapamycin, the mTOR kinase inhibitor, enhanced autophagy and promoted ATRA induced PML-RARa degradation and myeloid cell differentiation
Iwanami et al., Proc Natl Acad Sci U S A 2013 (Glioblastoma) : Direct mTOR inhibitors and EGF receptor (EGFR) inhibitors that block downstream mTOR signaling promote nuclear PML expression in GBMs, and genetic overexpression and knockdown approaches demonstrate that PML prevents mTOR and EGFR inhibitor dependent cell death