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HMOX1 — PPARA
Text-mined interactions from Literome
Krönke et al., Arterioscler Thromb Vasc Biol 2007
:
Here we investigate if the vasculoprotective and anti-inflammatory enzyme
heme oxygenase-1 (HO-1) is
regulated by
PPAR ligands in vascular cells ... Analysis of the human HO-1 promoter in transient transfection experiments together with mutational analysis and gel shift assays revealed a direct transcriptional
regulation of
HO-1 by
PPARalpha and PPARgamma via 2 PPAR responsive elements ... We demonstrate that
HO-1 expression is transcriptionally
regulated by
PPARalpha and PPARgamma, indicating a mechanism of anti-inflammatory and antiproliferative action of PPAR ligands via upregulation of HO-1
Lin et al., Am J Pathol 2010
(Drug-Induced Liver Injury...) :
Additionally, we revealed direct transcriptional
regulation of
HO-1 by the binding of PPARa to a
PPAR-responsive element (PPRE) by various experimental assessments
Burgess et al., Hypertension 2010
(Metabolic Syndrome X...) :
HO-1 induction
increased adiponectin, pAKT, pAMPK, and
PPAR? levels in adipocyte of obese animals
von Knethen et al., Free Radic Biol Med 2011
:
NADPH oxidase activation in either RAW264.7 cells or peritoneal macrophages ( PM ) derived from PPAR? wild-type mice increased reactive oxygen species ( ROS ) formation, caused
PPAR? activation,
heme oxygenase-1 (HO-1)
induction , and concomitant IFN-ß expression
Yang et al., World J Gastroenterol 2012
(Liver Cirrhosis) :
To investigate the
effects of
heme oxygenase (HO)-1 on liver fibrosis and the expression of peroxisome proliferator activated receptor gamma (
PPAR? ) and nuclear factor-kappa B ( NF-?B ) in rats
Liu et al., Arthritis Res Ther 2012
:
Our results suggest that the interaction between thrombin and
PAR1/PAR3 increases
HO-1 expression in human synovial fibroblasts through the PKCd, c-Src, and Nrf2 signaling pathways