Gene interactions and pathways from curated databases and text-mining

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GIF — TNF

Text-mined interactions from Literome

Roggia et al., Minerva Med 2004 (Osteoporosis) : In the following study of the research group of Prof. Pacifici it has been shown that the increased activation of TNF-alpha producing T-cell in the ovariectomized mice is due to increased INF-gamma levels, resulting from ovariectomy induced enhanced secretion of IL-12 and IL-18 by macrophages
Soliman et al., Jpn J Vet Res 2004 : INF-gamma induced dose dependent rises in the plasma levels of both cortisol and ACTH, while TNF-alpha induced comparable plasma cortisol responses with much smaller rises in plasma ACTH
Yang et al., J Pharmacol Exp Ther 2006 : The critical role of NADPH oxidase for GIF and PACAP38 neuroprotection against LPS induced DA neurotoxicity was demonstrated using neuron-glia cultures from mice deficient in NADPH oxidase ( PHOX ( -/- ) ), where PACAP38 and GIF reduced tumor necrosis factor alpha production and were neuroprotective only in PHOX ( +/+ ) cultures and not in PHOX ( -/- ) cultures
Sakai et al., Ther Apher Dial 2009 (Arthritis, Rheumatoid) : Infliximab (INF) , a tumor necrosis factor-alpha (TNF-alpha) inhibitor , is an effective drug for patients with rheumatoid arthritis ( RA )
Braun et al., Arterioscler Thromb Vasc Biol 1997 (Second Messenger Systems) : In cultured human smooth muscle cells from coronary arteries and saphenous veins, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) induced the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ), whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1