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RHOA — TNF

Text-mined interactions from Literome

Neumann et al., J Neurosci 2002 : TNF activated in neurons the small GTPase RhoA
Hunter et al., Mol Pharmacol 2003 : Tumor necrosis factor-alpha induced activation of RhoA in airway smooth muscle cells : role in the Ca2+ sensitization of myosin light chain20 phosphorylation ... In cultured human ASM cells, recombinant human TNF also activated RhoA with a similar time course
Segain et al., Gastroenterology 2003 (Colitis...) : In vitro, activation of RhoA alone was sufficient to induce tumor necrosis factor production
Sakai et al., J Smooth Muscle Res 2004 (Bronchial Hyperreactivity) : TNF-alpha augments the expression of RhoA in the rat bronchus
Tang et al., Life Sci 2006 : These data support the conclusion that TNFalpha signaling is under the negative control of RhoA and that statins potentiate TNFalpha signaling at least in part via interference with RhoA inhibition of TNFalpha type I receptor expression
Hunter et al., J Biol Chem 2006 : Lipid rafts are essential for TNF-alpha mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways ... Tumor necrosis factor (TNF)-alpha induced activation of RhoA , mediated by TNF receptor 1 (TNFR1), is a prerequisite step in a pathway that leads to increased 20-kDa light chain of myosin ( MLC20 ) phosphorylation and airway smooth muscle contraction ... In this study, we have investigated the proximal events in TNF-alpha induced RhoA activation ... TNF-alpha engagement of TNFR1 recruited the adaptor proteins TRADD, TRAF-2, and RIP into lipid rafts and activated RhoA , NF-kappaB, and MAPK pathways ... Targeted knockdown of caveolin-1 completely abrogated TNF-alpha induced RhoA activation, identifying this raft-resident protein as a positive regulator of the activation process ... Taken together, our results suggest that in airway smooth muscle cells, spatial compartmentalization of TNFR1 provides a mechanism for generating distinct signaling outcomes in response to ligand engagement and define a mechanistic role for lipid rafts and caveolin-1 in TNF-alpha induced activation of RhoA
Xu et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid) : This study was conducted to examine the role of RhoA in mediating the activation of NF-kappaB in tumor necrosis factor alpha (TNFalpha) stimulated rheumatoid synoviocytes, and to evaluate the modulatory effects of statins on the TNFalpha induced activation of RhoA and NF-kappaB and the secretion of proinflammatory cytokines by rheumatoid synoviocytes
Radeff-Huang et al., J Biol Chem 2007 (Brain Neoplasms...) : However, RhoA activation by TNF-alpha was not blocked by SphK inhibition
McKenzie et al., J Cell Physiol 2007 : TNF-alpha rapidly induced RhoA activation and myosin light chain phosphorylation, but caused only small changes to cortical F-actin, without significantly increasing paracellular permeability up to 30 min after stimulation
Rajesh et al., Am J Physiol Heart Circ Physiol 2007 (Disease Models, Animal...) : TNF-alpha induced NF-kappaB and RhoA activation and upregulation of adhesion molecules ICAM-1 and VCAM-1, increased expression of monocyte chemoattractant protein, enhanced transendothelial migration of monocytes, and augmented monocyte-endothelial adhesion
Mong et al., J Immunol 2008 (Pneumonia) : TNF-alpha induced a time dependent activation of RhoA and Rho kinase in these ECs
Yamashita et al., J Endocrinol 2008 (MAP Kinase Signaling System) : Simvastatin potently suppressed TNF-alpha induced phosphorylation of ERK1/2 and SAPK/JNK by inhibiting TNF-alpha induced membrane localization of Ras and RhoA
Kakiashvili et al., J Biol Chem 2009 : We show that TNF-alpha induced a rapid and sustained RhoA activation that led to stress fiber formation and Rho kinase dependent myosin light chain ( MLC ) phosphorylation
Bae et al., Thromb Haemost 2009 : Furthermore, similar to activated protein C, both thrombin and TRAP activated Rac1 and inhibited the activation of RhoA and NF-kappaB pathways in response to TNF-alpha in cells pretreated with protein C-S195A
Wu et al., American journal of physiology. Renal physiology 2009 (Nephritis) : Caspase inhibition also reduced TNF induced myosin light chain (MLC)-2 phosphorylation, and activation of upstream regulator RhoA
Cho et al., J Cell Biochem 2009 (Breast Neoplasms...) : Furthermore, KP10 inhibited TNFalpha induced cell migration and RhoA GTPase activation
Goto et al., Pharmacol Res 2010 : The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha induced RhoA transcriptions in human bronchial smooth muscle cells ... Luciferase based assay showed that the RhoA promoter activity was augmented by both IL-13 and TNF-alpha
Goto et al., Biol Pharm Bull 2010 (Asthma...) : The upregulation of RhoA induced by interleukin (IL)-13 and tumor necrosis factor (TNF)-alpha , major mediators for development of AHR, was observed in hBSMCs ... Increased expression and promoter activity of RhoA induced by TNF-alpha was completely inhibited by prednisolone, although the activation of NF-kappaB failed to be inhibited by prednisolone in hBSMCs ... These findings suggest that prednisolone might inhibit NF-kappaB induced transcription via interaction between glucocorticoid receptor ( GR ), resulting in an inhibition of RhoA upregulation induced by IL-13 and TNF-alpha
Kakiashvili et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We have previously shown that ERK mediated stimulation of the RhoA GDP/GTP exchange factor GEF-H1/Lfc is critical for TNF-a induced RhoA stimulation ... Surprisingly, TNF-a induced ERK and RhoA stimulation in tubular cells were prevented by epidermal growth factor receptor (EGFR) inhibition or silencing
Peng et al., Journal of neuroinflammation 2011 : Both pharmacological inhibitors and knockdown approaches were employed to investigate the role of PKC and p115RhoGEF in TNF-a induced RhoA activation and BMEC permeability ... Inhibition of conventional PKC by Gö6976 mitigated the TNF-a induced p115RhoGEF phosphorylation and RhoA activation ... These data suggest that PKC-a but not PKC-ß acts as an upstream regulator of p115RhoGEF phosphorylation and RhoA activation in response to TNF-a
Waheed et al., Mol Biol Cell 2013 : Central role of the exchange factor GEF-H1 in TNF-a induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells ... Taken together, our findings can explain the mechanisms leading to hierarchical activation of Rac and RhoA by TNF-a through a single GEF