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FOXP3 — IL10
Text-mined interactions from Literome
Schaub et al., Respir Res 2006
(Hypersensitivity, Immediate) :
Ppg induced
IL-10 production and
induction of
Foxp3 were higher in CBMC without, than with maternal atopy ( p = 0.04, p = 0.049 )
Caudy et al., J Allergy Clin Immunol 2007
(Genetic Diseases, X-Linked...) :
These data show that CD25 deficiency results in an IPEX-like syndrome and suggests that although
Foxp3 is not
required for normal
IL-10 expression by human CD4 lymphocytes, CD25 expression is important
Chaput et al., Gut 2009
(Adenocarcinoma...) :
Finally,
interleukin 6 and TGF beta 1 synergistically
induced the generation of CD8 ( + ) CD25 ( + )
Foxp3 ( + ) T cells ex vivo
Silva-Campa et al., Virology 2009
(Porcine Reproductive and Respiratory Syndrome) :
Analysis of the expressed cytokines suggested that the induction of
Foxp3 ( + ) CD25 ( + ) T cells is
dependent on TGF-beta but not
IL-10
Scholzen et al., PLoS Pathog 2009
(Malaria, Falciparum) :
Generation of
Foxp3 ( hi ), but not Foxp3 ( int ), cells specifically
required TGFbeta1 and
IL-10
Unutmaz et al., Nat Immunol 2009
(Colitis) :
A report in this issue describes a key
role for
interleukin 10 produced by lamina propria macrophages in maintaining
Foxp3 expression during inflammatory responses in the intestine
Heo et al., Immunol Lett 2010
(Arthritis, Rheumatoid) :
IL-10 induced
Foxp3 ( + ) regulatory T cells in the human CD4 ( + ) T cell population
Schmitz-Winnenthal et al., Gastroenterology 2010
(Carcinoma...) :
Pancreatitis-specific
IL-10 responses were
mediated by IL-10 ( + ) IFN-gamma ( - )
FoxP3 ( + ) regulatory T cells, which were expanded in the blood, bone marrow, and pancreatitis lesions and possessed the potential to suppress the proliferation of autologous conventional T cells in an antigen-specific manner
Hong et al., J Clin Immunol 2010
(Asthma...) :
Importantly, heat killed L. plantarum administration induced
Foxp3 expression in intestinal lamina propria cells, and heat killed L. curvatus
induced IL-10 as a way of inducing tolerance
Xie et al., Scand J Immunol 2010
:
The 4-antibodies approach
prevented lymphocytic infiltration in the grafts, inhibited memory T-cells proliferation in the spleen, increased
IL-10 secretion in the serum, and enhanced the expression of CD4 ( + )
Foxp3 ( + ) regulatory T cells ( Tregs ) in spleen
Round et al., Proc Natl Acad Sci U S A 2010
(Colitis) :
Functional
Foxp3 ( + ) Treg cells are also produced by PSA during intestinal inflammation, and Toll-like receptor 2 signaling is
required for both Treg induction and
IL-10 expression
Haque et al., PLoS Pathog 2010
(Malaria, Cerebral) :
Furthermore,
Foxp3 ( + ) cell mediated protection was
dependent upon CTLA-4 but not
IL-10
Huber et al., Immunity 2011
(Colitis...) :
Th17 cells express
interleukin-10 receptor and are
controlled by
Foxp3? and Foxp3+ regulatory CD4+ T cells in an interleukin-10 dependent manner
Trandem et al., J Virol 2011
(Acute Disease...) :
Additionally,
IL-10 increased both the frequency and number of
Foxp3 ( + ) regulatory CD4 T cells in the infected central nervous system
Liu et al., J Immunol 2011
(Colonic Neoplasms...) :
The suppressive activity of tumor associated
Foxp3 ( + ) CD4 ( + ) CD25 ( + ) regulatory T cells ( Treg ) was
IL-10 dependent
Vanvalkenburgh et al., J Exp Med 2011
(Inflammatory Bowel Diseases) :
These experiments demonstrate that Bcl11b is indispensable for T ( reg ) suppressor function and for maintenance of optimal Foxp3 and
IL-10 gene expression, as well as for the
induction of
Foxp3 expression in conventional CD4 ( + ) T cells in response to Tgf-ß and generation of iT ( reg ) cells
Hartmann et al., J Immunol 2011
(Filariasis) :
In contrast, we show that L. sigmodontis induced, host derived
IL-10 mediated
Foxp3 induction in transferred Th cells and significantly contributed to the observed Th cell hypoproliferation within infected mice
Elliott et al., Ann N Y Acad Sci 2012
(Immune System Diseases...) :
Helminth exposure tends to inhibit IFN-? and IL-17 production, promote IL-4,
IL-10 , and TGF-ß release,
induce CD4 ( + ) T cell
Foxp3 expression, and generate regulatory macrophages, dendritic cells, and B cells
van der Vlugt et al., PloS one 2012
(Hypersensitivity...) :
Splenic marginal zone CD1d ( + ) B cells proved to be the responsible splenic B cell subset as they produced high levels of
IL-10 and
induced FoxP3 ( + ) T cells in vitro
Urry et al., Eur J Immunol 2012
(Asthma) :
We demonstrate that the enhancement of
Foxp3 expression by 1a25VitD3 is
impaired by
IL-10
Wang et al., Parasitol Int 2013
(Malaria) :
In contrast, after DBA/2 was treatment with anti-IL-10R mAb,
IL-10R blockade in vivo
caused excessive pro-inflammation responses and
Foxp3 expression loss on CD4 ( + ) CD25 ( + ) T cells
Reilkoff et al., Am J Respir Crit Care Med 2013
(Disease Models, Animal...) :
In comparison to Sema 7a-CD4 ( + ) CD25 ( + ) FoxP3 ( + ) cells, Sema7a ( + ) CD4 ( + ) CD25 ( + )
FoxP3 ( + ) cells exhibit
reduced expression of regulatory genes such as
IL-10 , and adoptive transfer of these cells induces fibrosis and remodeling in the TGF-ß1 exposed murine lung
Wang et al., Transplantation 2013
(Graft vs Host Disease) :
Luciferase reporter assay showed that the expression of
IL-10 is directly
regulated by
Foxp3