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IL10 — MBP

Text-mined interactions from Literome

Aharoni et al., Proc Natl Acad Sci U S A 2000 (Encephalomyelitis, Autoimmune, Experimental) : This therapeutic effect was manifested, in brains of experimental autoimmune encephalomyelitis induced mice, by a decrease in the inflammatory cytokine interferon-gamma and by secretion of the anti-inflammatory cytokine IL-10 in response to the autoantigen MBP
Moldovan et al., J Neuroimmunol 2003 (Chronic Disease...) : MS patients showed significantly higher MBP induced IFNgamma responses and PLP induced IL-10 responses compared with healthy controls
Cabbage et al., J Immunol 2007 : Our results demonstrate that regulatory T cells induce naive MBP-specific T cells responding to nonactivated APCs to differentiate into a unique, tolerized state with the ability to produce IL-10 and TGF-beta1 in response to activated, but not nonactivated, APCs presenting MBP
Hedegaard et al., Immunology 2008 (Multiple Sclerosis, Relapsing-Remitting) : The MBP induced a dose dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient derived MNCs
Selmaj et al., Clin Exp Immunol 1988 (Multiple Sclerosis) : Multiple sclerosis : effect of myelin basic protein on interleukin 1, interleukin 2 production and interleukin 2 receptor expression in vitro
Link et al., Acta Neurol Scand Suppl 1994 (HIV Infections...) : Recombinant ( r ) TGF-beta 1 dose-dependently suppressed MBP induced upregulation of the proinflammatory cytokines IFN-gamma, IL-4, IL-6, tumor necrosis factor-alpha, ( TNF-alpha ), TNF-beta and perforin, but not of the immunosuppressive and probably advantageous IL-10