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Ríos et al., Exp Eye Res 2008
(MAP Kinase Signaling System) :
The purpose of the study was to determine if OPC-12759 stimulates secretion from conjunctival goblet cells in culture and if it activates the EGF receptor (EGFR) and p44/p42 mitogen activated protein kinase ( MAPK ) to cause mucin secretion
Román et al., Eukaryotic cell 2009
(Candidiasis) :
Msb2 signaling mucin controls activation of Cek1 mitogen activated protein kinase in Candida albicans
Besmer et al., Cancer Res 2011
(Carcinoma, Pancreatic Ductal...) :
Treatment with a MEK1/2 inhibitor, U0126, abrogated the enhanced proliferation of the KCM cells but had minimal effect on KCKO cells, suggesting that MUC1 is necessary for MAPK activity and oncogenic signaling
Kato et al., J Immunol 2012
(Lung Diseases...) :
However, overexpression of MUC1 in HEK293 cells did not affect NF-?B or MAPK activation in response to TNF-a