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GHR — IGF1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lang et al., Alcohol Alcohol 2000
(Body Weight) :
These data indicate that the decrease in hepatic IGF-I synthesis and plasma
IGF-I observed in alcohol fed rats was
independent of a change in
GHR levels
Tsukada et al., Growth Horm IGF Res 1998
:
These results indicate that thyroid hormones
regulate IGF-I production in the chicken by affecting hepatic
GHR expression
Lopez-Calderon et al., Eur J Endocrinol 2001
(Arthritis, Experimental) :
GH receptor (GHR) gene expression in the liver and the
effect of rhGH on hepatic
IGF-I synthesis in arthritic rats were examined
Radcliff et al., J Dairy Sci 2003
:
Reduced
GHR in liver likely
contributes to a decrease in liver
IGF-I production and reduced concentrations of IGF-I in blood of periparturient cows
Radcliff et al., J Dairy Sci 2004
(Weight Gain) :
Greater
IGF-I ( indicative of an increased GH response ) may be a
consequence of greater
GHR 1A expression in the liver
Oberbauer et al., Growth Dev Aging 2004
(Body Weight) :
The growth differential observed for the 0 vs. the 15 mM zinc stimulated transgenics may reflect the preferential increase in the full length
GH receptor mRNA and the
induction of the smaller
IGF-I transcripts with the higher circulating GH while the lipid accrual paralleled the disproportionate induction of the truncated GH receptor mRNA form
Iida et al., J Physiol 2004
:
Therefore, we investigated the effect of chronic GH excess or disruption of
GH receptor (GHR) signalling, and the acute
effect of GH administration on expression of muscle
IGF-I isoforms using transgenic mice that express bovine GH ( bGH ), GHR gene disrupted (GHR-/-) mice and GH-deficient lit/lit mice before and after exogenous GH administration
Shao et al., Am J Physiol Endocrinol Metab 2007
:
Finally, using growth hormone receptor (GHR) gene disrupted mice, we showed that regulation by E ( 2 ) of
IGF production was
independent of GH-induced
GHR signaling in mouse fallopian tubes in vivo
Arman et al., J Pediatr Endocrinol 2008
(Laron Syndrome) :
Interaction of GH with the
GH receptor (GHR) is
necessary for systemic and local production of
insulin-like growth factor-I (IGF-I) which mediates GH actions
Kraemer et al., Growth Horm IGF Res 2009
:
However, the absence of a functional
GHR did not
affect muscle
IGF-I protein expression compared to wildtype despite high circulating levels of GH and low circulating levels of IGF-I ... In conclusion, it appears that at rest high circulating levels of GH augment muscle IGF-I protein expression only in the
presence of an intact
GHR but that the absence of a functional GH receptor does not affect basal levels of muscle
IGF-I protein in female mice
Bornfeldt et al., J Endocrinol 1989
(Diabetes Mellitus, Experimental) :
While reduced
GH receptor gene expression may thus be
responsible for decreased
IGF-I gene expression in some states and tissues, additional regulatory mechanisms may be of importance
Wolf et al., Eur J Endocrinol 1996
:
Diminished GH receptor mRNA concentrations in response to IL-1 beta and TNF-alpha indicate that low
IGF-I levels during severe illness, despite high circulating GH levels, may at least partially be a
consequence of suppression of hepatic
GH receptor synthesis by IL-1 beta and TNF-alpha
Tönshoff et al., Endocrinology 1997
(Uremia) :
Our study shows that hepatic
IGF-I gene expression was specifically reduced in uremia, partially as the
consequence of a reduced hepatic
GH receptor gene expression