◀ Back to TNF
TNF — TRADD
Pathways - manually collected, often from reviews:
-
BioCarta sodd/tnfr1 signaling pathway:
SODD (BAG4)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
→
TRADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (active) (CASP2)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (CASP2)
(modification, activates)
-
BioCarta nf-kb signaling pathway:
TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
→
IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
JNKK1 (MAP2K4)
(modification, activates)
-
BioCarta nf-kb signaling pathway:
TNF-alpha (TNF)
→
TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
TNF-alpha (TNF)
→
TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
→
TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
MAP4K2
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD/Caspase 8 complex (CASP8-FADD)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 8 (CASP8)
(modification, activates)
-
BioCarta tnf/stress related signaling:
SODD (BAG4)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRAF2
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRADD
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
I-TRAF (TANK)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TRADD
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
MADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TRAF1
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
RAIDD (CRADD)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
SODD (BAG4)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
FADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TRADD
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
RAIDD (CRADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FADD (FADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
ASK1 (MAP3K5)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TRAF1 (TRAF1)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
cIAP2 (BIRC3)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
BAG4 (BAG4)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
Caspase 2 (CASP2)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A)
→
TRADD (TRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRADD (TRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Atypical PKCs (PRKCI/PRKCZ)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Atypical PKCs (PRKCI/PRKCZ)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
p62 (SQSTM1)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
p62 (SQSTM1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
Boldin et al., Cell 1996, Muzio et al., Cell 1996
Evidence: assay
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
NIK (MAP3K14)
(modification, activates)
Malinin et al., Nature 1997
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
CYLD (CYLD)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RFFL (RFFL)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
TRX/ASK1 complex (MAP3K5-TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
thioredoxin (TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caveolin-1 (CAV1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(translocation, activates)
Schütze et al., J Biol Chem 1999, D'Alessio et al., Am J Pathol 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TRADD (TRADD)
→
sTNF-alpha/TNFR1A complex (TNFRSF1A-TNF)
(modification, collaborate)
Hsu et al., Cell 1995, Jiang et al., Science 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TRADD (TRADD)
→
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
(modification, collaborate)
Hsu et al., Cell 1995, Jiang et al., Science 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A complex (TNFRSF1A-TNF)
→
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
(modification, collaborate)
Hsu et al., Cell 1995, Jiang et al., Science 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
→
NF kappa B1/RelA complex (NFKB1-RELA)
(modification, activates)
Sanz et al., EMBO J 1999, Leitges et al., Mol Cell 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RIP (RIPK1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RIP (RIPK1)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
A20 (TNFAIP3)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
None
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, inhibits)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Neutral sphingomyelinase II (SMPD3)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
Cathepsin D/ceramide complex (CTSD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Heinrich et al., Cell Death Differ 2004
Evidence: assay
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP1 (BIRC2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caspase 8 (CASP8)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD/PIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF-PIDD1)
→
Caspase 2 (CASP2)
(modification, activates)
-
NCI Pathway Database Ceramide signaling pathway:
cIAP2 (BIRC3)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRAF2 (TRAF2)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
BAG4 (BAG4)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RAIDD (CRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRADD (TRADD)
→
TNFR1A/BAG4/TNF-alpha complex (TNFRSF1A-BAG4-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRADD (TRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RIP (RIPK1)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
MADD (MADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TNFR1A/BAG4/TNF-alpha complex (TNFRSF1A-BAG4-TNF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
Reactome Reaction:
TNF
→
TRADD
(reaction)
Harper et al., J Biol Chem 2003*, Micheau et al., Cell 2003, Hsu et al., Cell 1995
-
Reactome Reaction:
TNF
→
TRADD
(indirect_complex)
Hsu et al., Cell 1995
-
WikiPathways Apoptosis:
TNF
→
Complex of TNFRSF21-TNFRSF1B-TNFRSF25-TRADD-TNFRSF10B-TNFRSF1A
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TNF
—
TRADD
(physical association, affinity chromatography technology)
Fu et al., Mol Cell Biol 2013
-
IRef Biogrid Interaction:
TNF
—
TRADD
(physical association, affinity chromatography technology)
Micheau et al., Cell 2003
-
IRef Biogrid Interaction:
TNF
—
TRADD
(physical association, affinity chromatography technology)
Legler et al., Immunity 2003
-
IRef Biogrid Interaction:
TNF
—
TRADD
(physical association, affinity chromatography technology)
Kuai et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
TNF
—
TRADD
(physical association, affinity chromatography technology)
Haas et al., Mol Cell 2009
-
IRef Biogrid Interaction:
TNF
—
TRADD
(physical association, affinity chromatography technology)
Ea et al., Mol Cell 2006
-
IRef Biogrid Interaction:
TNF
—
TRADD
(direct interaction, pull down)
Skaug et al., Mol Cell 2011*
-
IRef Intact Interaction:
Complex of BIRC2-RIPK1-TRADD-TNFRSF1A-TNF-TRAF2
(association, anti tag coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti tag coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of BIRC3-TNF-BIRC2-TRAF2-TRADD
(association, anti tag coimmunoprecipitation)
Jennewein et al., Oncogene 2012
Text-mined interactions from Literome
De Nadai et al., Proc Natl Acad Sci U S A 2000
(Second Messenger Systems) :
In combination with TNF-alpha, however, ceramide potentiated, whereas NO inhibited,
TNF-alpha induced
TRADD recruitment and caspase 8 activity
Wang et al., Mol Cell Biol 2000
:
Examination of Stat1-deficient cells showed an apparent increase in
TNF-alpha induced
TRADD-RIP and TRADD-TRAF2 complex formation, while interaction between TRADD and FADD was unaffected
Vanden Berghe et al., Mol Cell 2007
(Necrosis) :
In a recent issue of Molecular Cell, Kim et al. ( 2007 ) reported on a novel
TNF receptor 1 necrotic signaling complex
inducing TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 NADPH oxidase complex
Kieser et al., Biol Chem 2008
:
Pursuing different ` TRADDes ' :
TRADD signaling
induced by
TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1 ... Upon
stimulation with the pro-inflammatory cytokine
TNFalpha ,
TRADD is recruited to the activated TNFR1 by direct interaction between the death domains of both molecules
Misaki et al., Am J Pathol 2009
(Kidney Diseases...) :
Both ubiquitination and degradation of TRADD were increased in UUO kidneys, degradation of
TRADD was
stimulated by
TNFalpha in HK-2 cells, and TRADD degradation was suppressed by proteasome inhibitor ... Inhibition of
TNFalpha by soluble TNFR2, etanercept, reduced significantly, although transiently, tubular and interstitial cell proliferation, fibronectin expression, and apoptosis in UUO kidneys, and also
suppressed TRADD degradation
Pobezinskaya et al., J Immunol 2011
:
The adaptor protein
TRADD is
essential for
TNF-like ligand 1A/death receptor 3 signaling
Shu et al., Proc Natl Acad Sci U S A 1996
:
The recruitment of TRAF2 and c-IAP1 to TNF-R1 is
TNF dependent, is
mediated by
TRADD , and is independent of TNF-R2