Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

TNF — TRADD

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

De Nadai et al., Proc Natl Acad Sci U S A 2000 (Second Messenger Systems) : In combination with TNF-alpha, however, ceramide potentiated, whereas NO inhibited, TNF-alpha induced TRADD recruitment and caspase 8 activity
Wang et al., Mol Cell Biol 2000 : Examination of Stat1-deficient cells showed an apparent increase in TNF-alpha induced TRADD-RIP and TRADD-TRAF2 complex formation, while interaction between TRADD and FADD was unaffected
Vanden Berghe et al., Mol Cell 2007 (Necrosis) : In a recent issue of Molecular Cell, Kim et al. ( 2007 ) reported on a novel TNF receptor 1 necrotic signaling complex inducing TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 NADPH oxidase complex
Kieser et al., Biol Chem 2008 : Pursuing different ` TRADDes ' : TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1 ... Upon stimulation with the pro-inflammatory cytokine TNFalpha , TRADD is recruited to the activated TNFR1 by direct interaction between the death domains of both molecules
Misaki et al., Am J Pathol 2009 (Kidney Diseases...) : Both ubiquitination and degradation of TRADD were increased in UUO kidneys, degradation of TRADD was stimulated by TNFalpha in HK-2 cells, and TRADD degradation was suppressed by proteasome inhibitor ... Inhibition of TNFalpha by soluble TNFR2, etanercept, reduced significantly, although transiently, tubular and interstitial cell proliferation, fibronectin expression, and apoptosis in UUO kidneys, and also suppressed TRADD degradation
Pobezinskaya et al., J Immunol 2011 : The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling
Shu et al., Proc Natl Acad Sci U S A 1996 : The recruitment of TRAF2 and c-IAP1 to TNF-R1 is TNF dependent, is mediated by TRADD , and is independent of TNF-R2