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CSRP1 — NFKB1
Text-mined interactions from Literome
Agrawal et al., Immunology 2003
:
They raise the possibility, not as yet established, that
NF-kappaB activation may be responsible for the synergistic
effect of IL-1beta on IL-6 induced
CRP expression
Ikeda et al., J Cardiovasc Pharmacol 2003
:
Addition of IL-1beta activated nuclear factor-kappaB (NFkappaB) in VSMCs, whereas
CRP did not
affect IL-1beta induced
NFkappaB activation
Ramage et al., Inhal Toxicol 2004
:
It was also found that this expression of
CRP with CB and ufCB treatments was
dependent on
nuclear factor kappa B (NFkappaB)
Voleti et al., J Immunol 2005
:
In this study we show that
NF-kappaB requires and acts synergistically with C/EBPbeta on the CRP-proximal promoter to
regulate CRP expression
Chang et al., Nephron. Experimental nephrology 2005
(Inflammation) :
We investigated the
effects of
CRP on the
nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 ( MCP-1 ) gene expression in human mesangial cells and also examined whether intracellular calcium and reactive oxygen species ( ROS ) were involved in the CRP- induced NF-kappaB activation
Lin et al., Biol Pharm Bull 2005
:
By using an electrophoretic mobility shift assays ( EMSA ), we found that
CRP ( 50 microg/ml )
increased activation of
NF-kappaB and degradation of inhibitory kappa B ( IkappaB ) in HUVECs, reaching a maximal effect after the incubation with CRP for 1 h. Lovastatin ( 10 ( -5 ) mol/l ) diminished NF-kappaB activation induced by CRP
Liang et al., J Mol Cell Cardiol 2006
:
In conclusion,
CRP induced IkappaB degradation,
NF-kappaB nuclear translocation and VCAM-1 protein expression in HUVECs and HAECs
Devaraj et al., Am J Physiol Heart Circ Physiol 2006
:
Preincubation with antibodies to CD32 and CD64 or transient transfection with small interference RNA to CD32 attenuated
CRP induced
NF-kappaB activity, ICAM, VCAM, and monocyte-endothelial cell adhesion under static conditions
Chen et al., FEBS Lett 2009
(MAP Kinase Signaling System) :
CRP could also
increase protein expression of phosphorylated
nuclear factor-kappaB (NF-kappaB) , IkappaB-alpha and ERK1/2 in dose- and time dependent manner