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ADAM12 — NOTCH3

Text-mined interactions from Literome

Huovila et al., Trends Biochem Sci 2005 : The recent studies have also begun to elucidate the substrate specificity and the mechanisms that control ADAM mediated shedding events that regulate, for example, growth-factor and Notch signalling, and the processing of the amyloid precursor protein
Dyczynska et al., J Biol Chem 2007 : Our findings expand the role of ADAM proteins in the regulation of Notch signaling
Zolkiewska et al., Cell Mol Life Sci 2008 : ADAM mediated cleavage of Notch represents the first step in regulated intramembrane proteolysis of the receptor, leading to activation of the Notch pathway
Li et al., J Biol Chem 2011 : Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29 ... We report here that ADAM12 expression in cultured mammalian cells is up-regulated by Notch signals ... Up-regulation of ADAM12 expression by Notch requires new transcription, is activated in a CSL dependent manner, and is abolished upon inhibition of I?B kinase ... We further show that the microRNA-29 family, which has a predicted conserved site in the 3'-untranslated region of mouse Adam12, plays a critical role in mediating the stimulatory effect of Notch on ADAM12 expression