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PRL — RAF1
Text-mined interactions from Literome
Romano et al., Endocrinology 2006
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Regulation of the
RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and
prolactin release by the phosphoinositide 3-kinase/AKT pathway in pituitary cells
Clevenger et al., J Biol Chem 1994
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We demonstrate here that
PRL induced the phosphorylation of the p72-74 serine/threonine kinase
c-Raf-1 in the PRL dependent rat T-cell line Nb2. Associated with this inducible phosphorylation of Raf-1 was a concentration- and time dependent activation of in vitro Raf-1 autokinase and substrate kinase activities, which correlated with the PRL induced proliferation of Nb2 cells