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CPOX — RHOA

Text-mined interactions from Literome

Thomas et al., Infect Immun 2001 : Here we demonstrate for the first time, by using a luciferase based reporter system, that the transcription of cyclooxygenase-2 (COX-2) is strongly upregulated in NIH 3T3 fibroblasts treated with CNF and that this effect is dependent upon the activation of RhoA by the toxin
Benitah et al., Mol Biol Cell 2003 (Neoplasms, Experimental) : Herein, we demonstrate that RhoA , Rac1, and Cdc42 promote the expression of cyclooxygenase-2 (COX-2) at the transcriptional level by a mechanism that is dependent on the transcription factor nuclear factor-kappaB (NF-kappaB), but not Stat3, a transcription factor required for RhoA induced tumorigenesis