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CTNND1 — RHOA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RHOA/GDP complex (RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
p120 catenin/RhoA/GDP complex (CTNND1-RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
p120 catenin/RhoA/GDP complex (CTNND1-RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
RHOA/GDP complex (RHOA)
→
p120 catenin/RhoA/GDP complex (CTNND1-RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Anastasiadis et al., Nat Cell Biol 2000, Yamada et al., J Cell Biol 2007, Braga et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database N-cadherin signaling events:
RHOA/GDP complex (RHOA)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Charrasse et al., J Cell Biol 2002, Comunale et al., Biol Cell 2007
Evidence: assay, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
CTNND1
—
RHOA
(interaction, mapped from grid kegg_pathways)
-
STRING interaction:
RHOA
—
CTNND1
(interaction, mapped from grid kegg_pathways)
Text-mined interactions from Literome
Wittchen et al., Mol Biol Cell 2003
:
We also provide evidence that NZO-3 interacts directly with the C terminus of ZO-3, and we propose a model where altered interactions between ZO-3 and
p120 catenin in NZO-3 expressing cells
affect RhoA GTPase activity
Kabuyama et al., Mol Cell Proteomics 2006
:
Thus, protein profiling reveals a novel role for PTP1B as a mediator of
RhoA dependent phosphorylation of
p130Cas
Tu et al., J Invest Dermatol 2011
:
Suppressing endogenous
Rho A expression by small interfering RNA ( siRNA ) -mediated gene silencing blocked the Ca ( 2+ ) ( o ) -induced association of Fyn with E-cadherin and
suppressed the Ca ( 2+ ) ( o ) -induced tyrosine phosphorylation of ß-, ?-, and
p120-catenin and formation of intercellular adherens junctions