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PRKACB — TRPV1

Text-mined interactions from Literome

Bhave et al., Neuron 2002 (Pain) : In this study, we demonstrate that PKA reduces VR1 desensitization and directly phosphorylates VR1 ... Electrophysiological analysis of phosphorylation site mutants clearly pinpoints Ser116 as the residue responsible for PKA dependent modulation of VR1
Vetter et al., Eur J Pain 2008 (Ion Channel Gating) : Since the mu opioid receptor (MOP) agonist morphine can inhibit TRPV1 responses potentiated by cAMP dependent protein kinase A (PKA), and ethanol mediated modulation of other ion channels involves activation of PKA , we aimed to assess the contribution of MOP-sensitive pathways to the potentiation of TRPV1 mediated capsaicin responses by ethanol
Schnizler et al., J Neurosci 2008 (Hyperalgesia) : In functional studies, PKA stimulation with forskolin markedly reduced desensitization of TRPV1
Sántha et al., Acta Physiol Hung 2010 : These findings suggest that activation of the CB1 receptor can reduce the activity of TRPV1 in primary sensory neurons, and that this inhibitory effect could be mediated through the reduction of PKA mediated phosphorylation of TRPV1
Por et al., Biochem J 2013 : Pharmacological activation of the kinases PKA ( protein kinase A ) and PKC ( protein kinase C ) led to a robust increase in TRPV1 and ß-arrestin-2 association, whereas inhibition of PKA and PKC decreased association
Spahn et al., Pain 2013 (Disease Models, Animal...) : Inhibition of AC and PKA , as well as mutations of the PKA phosphorylation sites threonine 144 and serine 774, prevented the enhanced TRPV1 activity