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INS — IRF6

Text-mined interactions from Literome

Sugita et al., Am J Physiol Endocrinol Metab 2002 (Hyperglycemia...) : Inducible nitric oxide synthase plays a role in LPS induced hyperglycemia and insulin resistance
Soop et al., Am J Physiol Endocrinol Metab 2002 (Diabetes Mellitus, Type 2...) : In vitro studies showed no modulation of LPS stimulated IL-6 or TNF-alpha production by glucose, insulin , or leptin at physiologically relevant concentrations
Vives-Pi et al., Clin Exp Immunol 2003 : In vitro experiments using rat islets ( also positive for CD14 by RT-PCR ) and HP62 cells showed that LPS regulates glucose dependent insulin secretion and induces inflammatory cytokines [interleukin (IL)-1alpha, IL-6 and tumour necrosis factor (TNF)-alpha ]
Doherty et al., Cytokine 1992 : Adrenocorticotrophic hormone ( ACTH ) and insulin increased supernatant levels of TNF bioactivity in response to LPS , while each decreased available TNF-alpha gene transcripts
Orellana et al., Am J Physiol Endocrinol Metab 2007 (Endotoxemia...) : In the presence of fasting insulin and amino acids, LPS reduced protein synthesis in longissimus dorsi ( LD ) and gastrocnemius muscles and increased protein synthesis in the diaphragm, but had no effect in masseter and heart muscles
Cao et al., J Nutr 2008 (Inflammation) : TTP expression is reduced in fats of obese people with metabolic syndrome and brains of suicide victims and is induced by insulin and cinnamon polyphenol extract (CPE) in adipocytes, by lipopolysaccharide (LPS) in macrophages, and by green tea polyphenol extract in rats
Kiely et al., J Endocrinol 2009 : We have now extended this area of research and have determined the effects of LPS on cell viability, insulin secretion, insulin signalling and metabolism in a clonal beta-cell line ... Incubation of BRIN-BD11 cells for 24 h in the presence of increasing concentrations of the TLR4 ligand LPS significantly decreased chronic ( 24 h ) insulin secretion from 1.09+/-0.19 to 0.76+/-0.18 microg insulin/mg protein in the presence of 100 ng/ml LPS ( P < 0.05 )
Pang et al., Neuroscience 2010 : Furthermore, microglia derived insulin-like growth factor-1 (IGF-1) and ciliary neurotrophic factor (CNTF) were significantly suppressed by LPS , and exogenous IGF-1 and CNTF synergistically protected OLs from death induced by LPS treated microglia conditioned medium, indicating that a deficiency in trophic support may also be involved in OL death
Wilden et al., Proc Natl Acad Sci U S A 1990 : The phosphotransferase activity of the dephospho form of both the IR and IRF1146 toward exogenous substrates was stimulated 3- to 4-fold by insulin
Amyot et al., PloS one 2012 : LPS repression of insulin, PDX-1 and MafA expression, as well as its inhibition of insulin secretion, were not observed in islets from TLR4-deficient mice
Buhl et al., J Clin Endocrinol Metab 2013 (Insulin Resistance) : Leg blood flows, phenylalanine, lactate kinetics, cytokines, and intramyocellular insulin signaling were not affected by LPS
Corbett et al., J Exp Med 1995 : Although TNF+LPS induce iNOS expression and inhibit insulin secretion by intact islets, this combination does not induce the expression of iNOS by beta or alpha cells purified by fluorescence activated cell sorting ( Facs ) ... Evidence suggests that TNF+LPS inhibit insulin secretion from islets by stimulating the release of IL-1 which subsequently induces the expression of iNOS by beta cells ... The IL-1 receptor antagonist protein completely prevents TNF+LPS induced inhibition of insulin secretion and attenuates nitrite formation from islets, and neutralization of IL-1 with antisera specific for IL-1 alpha and IL-1 beta attenuates TNF+LPS induced nitrite formation by islets ... Local release of IL-1 within islets appears to be required for TNF+LPS induced inhibition of insulin secretion because TNF+LPS do not stimulate nitrite formation from islets physically separated into individual cells
Bundz et al., Shock 1995 : LPS reduced plasma insulin ( 54 % ), and increased glucagon ( 270 % ), corticosterone ( 180 % ), and tumor necrosis factor concentrations in plasma ( peak 3200-4600 pg/mL at 90 min ), with no modification by NAL pretreatment
Leeper-Woodford et al., Am J Physiol 1997 : We monitored the effects of LPS and epinephrine on TNF and insulin activity of isolated Wistar-Furth rat islets ( pancreas digested with collagenase, islets isolated using Ficoll gradients ; n = 4 islet populations, each with 632 +/- 11 islets/2.5 ml culture medium )
Arnush et al., J Clin Invest 1998 : Inhibition of iNOS activity by aminoguanidine also attenuates TNF + LPS + IFN-gamma induced inhibition of insulin secretion by human islets