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EDN1 — HSPG2

Text-mined interactions from Literome

Mittmann et al., Naunyn Schmiedebergs Arch Pharmacol 2001 : Additionally, both RGS proteins reduced basal and endothelin stimulated PLC activity in these membranes by about 40 %
Nasuhoglu et al., Am J Physiol Cell Physiol 2002 : Total PIP and PIP2 levels ( 10-30 micromol/kg wet weight ) do not change, or even increase, with activation of Galpha ( q ) /phospholipase C (PLC) dependent pathways by carbachol ( 50 microM ), phenylephrine ( 50 microM ), and endothelin-1 ( 0.3 microM )
Thomas et al., Am J Physiol 1991 : The mechanisms of stimulation of phospholipase C (PLC) by endothelin , specifically the role of guanine nucleotide binding proteins ( GTP binding proteins ) in coupling the endothelin receptor to PLC, were investigated in rat mesangial cells
Ambar et al., Eur J Pharmacol 1993 (Glioma) : The activation of PLC or PLD by endothelin in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+
Lamers et al., J Cardiovasc Pharmacol 1995 (Cardiomegaly) : We have previously demonstrated that stimulation of cultured rat neonatal cardiomyocytes by endothelin-1 (ET-1) induces rapid activation of phospholipase C-beta (PLC-beta) , accompanied by transient expression of proto-oncogenes and subsequent development of hypertrophy and characteristic phenotypic changes
Dokhac et al., J Cardiovasc Pharmacol 1995 : In estrogen treated rat myometrium, endothelin-1 (ET-1) activated both the phospholipase C (PLC) which degrades PtdInsP2, resulting in an increased accumulation of inositol phosphates, and the phospholipase D pathway ( PLD ) as evidenced in the presence of butanol by an increased production of phosphatidylbutanol ( PBut )
Matsumoto et al., Invest Ophthalmol Vis Sci 1996 (Second Messenger Systems) : To characterize the pharmacology of endothelin induced changes in phospholipase C (PLC) activity, intracellular calcium concentration ( [ Ca2+ ] i ) and cyclic adenosine monophosphate ( cAMP ) in cultured human ciliary muscle ( HCM ) cells ... Endothelin-1 (ET-1) stimulated PLC ( mean EC50 = 335 pM ) and activated calcium mobilization in HCM cells
Nord et al., Clin Exp Pharmacol Physiol 1996 : 5. Phosphatidylcholine-specific phospholipase C ( PC-PLC ) is stimulated by endothelin and accounts for the prolonged activation of diacylglycerol by this peptide
Haque et al., Curr Eye Res 1998 : Endothelin-1 ( ET-1 ; 1 microM ) stimulated PLC in HTM-16 cells, but Sarafotoxin S6c ( SRTX ), an ET ( B ) receptor subtype-selective agonist ( 1 microM ), did not