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CASP2 — IL1B

Text-mined interactions from Literome

Pirhonen et al., J Immunol 1999 : Since caspase-1 is known to cleave proIL-1 beta and proIL-18 into their mature, active forms, we analyzed the effect of a specific caspase-1 inhibitor on virus induced IL-1 beta and IL-18 production ... Furthermore, the virus induced activation of caspase-1 is required for the efficient production of biologically active IL-1 beta and IL-18
Zeuner et al., Cell Death Differ 1999 : In addition to the well established role of caspase-1 in the production of active IL-1beta and IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis
Laliberte et al., J Biol Chem 1999 : Characterization of the pharmacological sensitivity of this stimulus coupled response revealed that some caspase-1 inhibitors allow pro-IL-1beta secretion, whereas others do not
Humke et al., Cell 2000 : ICEBERG is a novel protein that inhibits generation of IL-1beta by interacting with caspase-1 and preventing its association with RIP2
Nonaka et al., J Periodontal Res 2001 : IL-1beta secretion was blocked by the caspase-1 inhibitor, Z-VAD-FMK, indicating that caspase-1 is involved in not only the induction of apoptosis but also the IL-1beta secretion from A. actinomycetemcomitans infected J774.1 cells
Lee et al., J Biol Chem 2001 : The production of bio-active interleukin-1beta (IL-1beta) , a pro-inflammatory cytokine, is mediated by activated caspase-1
Carpenter et al., Diabetes 2002 : That IL-1beta also activated caspase-3 and promoted PKCdelta cleavage suggests that this distal pathway also contributes in the apoptotic response to the cytokine
Lynch et al., Eur J Neurosci 2002 (MAP Kinase Signaling System) : Analysis of colocalization of activated caspase-3 with activated p38 ( p-p38 ) suggested that p-p38 was necessary for activation of caspase-3 ; while in vitro analysis indicated that the IL-1beta induced increase in caspase-3 activity was abrogated by the p38 inhibitor, SB203580 ... The IL-1beta induced increase in caspase-3 activity in vitro was also abrogated by vasoactive intestinal peptide, which is a JNK inhibitor ; however, colocalization of activated JNK ( p-JNK ) and activated caspase-3 did not clearly identify JNK as an upstream activator of caspase-3
Martinon et al., Mol Cell 2002 (Inflammation) : Generation of Interleukin (IL)-1beta via cleavage of its proform requires the activity of caspase-1 ( and caspase-11 in mice ), but the mechanism involved in the activation of the proinflammatory caspases remains elusive
Schauvliege et al., J Biol Chem 2002 : Murine caspase-11 , together with caspase-1, is essential for the production of IL-1beta in response to lipopolysaccharide (LPS)
Kang et al., Cell Death Differ 2002 (Disease Models, Animal...) : The early activation of caspases-3/-7 by caspase-11 was not affected by blocking of caspase-1 activity and IL-1beta release, implying that caspase-11 activates caspases-3/-7 independently of caspase-1 activation
Evans et al., Gastroenterology 2002 (Inflammatory Bowel Diseases) : In peripheral blood mononuclear cells, inhibition of caspase 1 reduced interleukin-1beta secretion, whereas blockade of phagocytosis inhibited calcium induced apoptosis and interleukin-1beta release
Yoo et al., Biochem Biophys Res Commun 2002 : The production of bioactive interleukin-1beta (IL-1beta) , a pro-inflammatory cytokine, is mediated by activated caspase-1 ... Nod1 enhances caspase-1 induced IL-1beta secretion, as well as lipopolysaccharide (LPS) induced IL-1beta secretion in transfected cells
Wang et al., Br J Pharmacol 2003 (Hypercholesterolemia...) : 8. This study demonstrates that injection of a selective caspase-1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia-reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of IL-1beta production and activation of caspase-1 and caspase-3
Stuyt et al., Cytokine 2003 : Inhibition of caspase-1 reduced IFN-gamma and IL-1beta levels ( by 80 and 67 %, respectively ) when heat killed S. epidermidis was added to whole human blood cultures
Jendrossek et al., Infect Immun 2003 : In addition, only the piliated wild-type strains induced caspase-1 mediated activation of interleukin-1 beta
Stehlik et al., J Biol Chem 2003 : In contrast to its effects on Nod1- and Cardiak dependent NF-kappa B activation, CARD6 did not interfere with caspase-1 dependent interleukin-1 beta secretion induced by Cardiak or Nod1
Chen et al., Biochem Pharmacol 2003 : Novel roles for palmitoylation of Ras in IL-1 beta induced nitric oxide release and caspase 3 activation in insulin secreting beta cells ... CER-treatment also prevented IL-1 beta induced activation of caspase 3 in these cells
Fortunato et al., Placenta 2003 : When compared to control, IL-1 beta increased caspase 2, 3, 8 and 9 activities, whereas IL-6 treated membranes did not exhibit a significant change
Donnelly-Roberts et al., J Pharmacol Exp Ther 2004 (MAP Kinase Signaling System) : Two caspase inhibitors, YVAD ( caspase 1 ) and DEVD ( caspase 3 ), attenuated both BzATP induced pore formation and IL-1beta release in a concentration dependent fashion ... In contrast, P2X(7)R mediated IL-1beta release is dependent on caspase activity but not p38 MAPK
Veluthakal et al., Am J Physiol Cell Physiol 2004 : N ( G ) -monomethyl-l-arginine, a known inhibitor of inducible nitric oxide synthetase (iNOS), markedly inhibited IL-1beta induced iNOS gene expression, NO release, caspase-3 and caspase-6 activation, lamin B degradation, and loss of metabolic cell viability, indicating that the observed IL-1beta induced effects on nuclear lamin B involve the intermediacy of NO
Basak et al., J Biol Chem 2005 (MAP Kinase Signaling System) : NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1 mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide stimulated macrophages
Cooke et al., Transplantation 2005 : In addition, AdvBcl-2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft IL-1beta production and inhibited intragraft caspase-3 and caspase-9 activity
Ubol et al., Microbiol Immunol 2005 (Disease Models, Animal...) : The first is immune mediated death which may operate through the receptor-ligand pathway activated by caspase-1 and the pro-inflammatory cytokine, IL-1beta
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
El Btaouri et al., Biochem Biophys Res Commun 2006 (MAP Kinase Signaling System) : The permeable exogenous C ( 2 ) -ceramide reproduces IL-1beta effects on: (i) inhibition of adenylyl cyclase activity, ( ii ) down-regulation of ERK1/2 phosphorylation, ( iii ) activation of caspase-3 , and ( iv ) apoptosis in pig thyroid cells
Shakibaei et al., Ann Anat 2005 : Additionally, curcumin antagonized IL-1beta induced caspase-3 activation in a time dependent manner
Okemoto et al., J Immunol 2006 : A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1
MacRae et al., J Endocrinol 2006 : TNFalpha but not IL-1beta exposure led to increased caspase-3 activity and altered cellular morphology, consistent with reduced viability
Dorfleutner et al., Infect Immun 2007 (Inflammation) : cPOP2 binds to ASC and PAN1, thereby blocking formation of cryopyrin and PAN1 containing inflammasomes, activation of caspase-1 , and subsequent processing and secretion of bioactive interleukin-1beta
Dinarello et al., Semin Nephrol 2007 (Inflammation...) : IL-18 is a member of the IL-1 family ; IL-1beta and IL-18 are related closely, and both require the intracellular cysteine protease caspase-1 for biological activity
Boost et al., Intensive Care Med 2007 (Endotoxemia) : Targeting caspase-1 by inhalation-therapy : effects of Ac-YVAD-CHO on IL-1 beta , IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
Shakibaei et al., Ann N Y Acad Sci 2007 : Resveratrol inhibits IL-1 beta induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
Ikeda et al., J Immunol 2007 (MAP Kinase Signaling System) : The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP binding cassette transporter, and caspase-1
Li et al., J Immunol 2007 : Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release
Dinarello et al., Immunity 2007 (Inflammation) : Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor ( TLR ) signaling
Ahmed et al., J Vet Med Sci 2007 : However, leptin treatment increased monocyte/macrophages production of IL-1beta as well as TNF-alpha, and induced the mRNA expression of caspase-1 , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms
Moore et al., Synapse 2007 (Disease Models, Animal...) : In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the IL-1beta induced increases in activation of JNK and caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3
Schroeder et al., Microbiology 2007 : Addition of CCCP 15 min after infection blocked macrophage cell death, the activation of caspase-1 and the maturation of IL-1beta , without affecting uptake or escape of S. flexneri from the phagosome
Holohan et al., J Cell Mol Med 2008 (Insulinoma) : The broad range caspase inhibitor, Boc-D-fmk, blocked IL-1beta/IFNgamma -induced caspase activity, but not nitric oxide production nor cell death
Kuijk et al., Mol Immunol 2008 : Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1 ... Taken together, these results demonstrate that simvastatin augments LPS induced IL-1beta release post-translationally, by inducing caspase-1 activity
Miao et al., Proc Natl Acad Sci U S A 2008 : We demonstrate here that Pseudomonas aeruginosa activates caspase 1 and induces IL-1beta secretion in infected macrophages
Rupper et al., Infect Immun 2008 : The activation of caspase-1 by the detection of bacterial products through Nod-like receptors leads to the secretion of mature interleukin-1beta (IL-1beta) and IL-18 and the induction of rapid host cell death ( pyroptosis )
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Coppola et al., Int J Biochem Cell Biol 2008 : In beta-TC3 cells, NT activates both MAP and PI-3 kinases pathways and strongly reduces the staurosporine or the Il-1beta induced caspase-3 activity by a mechanism involving Akt activation
Pelegrin et al., J Immunol 2008 : We delineated two distinct release pathways : the well-known caspase-1 cascade mediating release of processed IL-1beta that was selectively blocked by inhibition of caspase-1 or panx1, and a calcium independent, caspase-1/panx1 independent release of pro-IL-1beta that was selectively blocked by glycine
Kang et al., Eur J Immunol 2008 (Anthrax) : In contrast, we now report that caspase-1 mediated IL-1beta expression in response to BA spores is required for anti-BA host defenses
Hsu et al., Proc Natl Acad Sci U S A 2008 (Anthrax...) : A NOD2-NALP1 complex mediates caspase-1 dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
Hewinson et al., J Immunol 2008 (Ion Channel Gating) : Inflammatory caspase-1 is responsible for the proteolytic activation of IL-1beta
Yajima et al., Circulation 2008 (Inflammation...) : Apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates caspase-1 dependent IL-1 beta and IL-18 generation ; however, the role of ASC in vascular injury remains undefined
Li et al., J Immunol 2008 (Inflammation) : We have recently shown that alum activates caspase-1 and induces secretion of mature IL-1beta and IL-18
Shakibaei et al., Biochem Pharmacol 2008 (Osteoarthritis) : Furthermore, we observed that resveratrol as well as ALLN inhibited IL-1beta induced apoptosis, caspase-3 activation and PARP cleavage in human articular chondrocytes
Kuijk et al., Blood 2008 (Mevalonate Kinase Deficiency) : HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation ... IL-1beta release is mediated by caspase-1 , and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner
Maelfait et al., J Exp Med 2008 (Inflammation) : These results implicate a novel role for caspase-8 in the production of biologically active IL-1beta in response to TLR3 and TLR4 stimulation
González-Benítez et al., Mediators Inflamm 2008 (Inflammation) : In the inflammosome complex, NALP3 or NALP1 binds to ASC and activates caspase-1 which induces IL-1beta
Deng et al., Toxicol Appl Pharmacol 2009 (Periodontitis) : Furthermore, caspase-1, a promoter of IL-1beta production, was activated by treatment with alendronate, and caspase-1 inhibitor reduced the production of IL-1beta induced by alendronate and P. gingivalis
Wang et al., Stroke 2009 (Brain Ischemia...) : Mitochondrial membrane potential, release of apoptogenic mitochondrial factors, pro-IL-1beta processing, and activation of caspase -1 and -3 were evaluated ... Methazolamide and melatonin inhibit oxygen/glucose deprivation induced cell death, loss of mitochondrial membrane potential, release of mitochondrial factors, pro-IL-1beta processing, and activation of caspase-1 and -3 in primary cerebrocortical neurons
Hise et al., Cell Host Microbe 2009 (Candidiasis...) : The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription, whereas the NLRP3 containing proinflammatory multiprotein complex, the NLRP3 inflammasome, controls caspase-1 mediated cleavage of pro-IL-1beta
Zaiss et al., J Immunol 2009 (Adenoviridae Infections) : In direct correlation with the increased viral internalization, antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes, type I IFNs, and caspase dependent IL-1beta maturation
Talabot-Ayer et al., J Biol Chem 2009 : Consistently, caspase-1 activation in THP-1 cells induced cleavage of pro-IL-1beta but not of pro-IL-33, and activated THP-1 cells released full-length pro-IL-33 into culture supernatants
Franchi et al., J Immunol 2009 (Inflammation) : In addition to TNF-alpha, IL-1alpha and IL-1beta promoted caspase-1 activation via Nlrp3 in response to ATP
Muñoz-Planillo et al., J Immunol 2009 (Inflammation...) : In this study, we show that the ability of Staphylococcus aureus, a leading cause of infection in humans, to activate caspase-1 and induce IL-1beta secretion resides in culture supernatants of growing bacteria
Cho et al., Infect Immun 2010 : Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte derived dendritic cells
Prantner et al., Infect Immun 2009 (Chlamydia Infections) : By using LPS primed macrophages as a model system, it was determined that IL-1beta secretion was dependent on caspase-1 , potassium efflux, and the activity of serine proteases
Becker et al., J Biol Chem 2009 : Rab39a binds caspase-1 and is required for caspase-1 dependent interleukin-1beta secretion
Honsho et al., Circ Res 2009 (Endomyocardial Fibrosis...) : IL-1beta deficiency markedly increased c-Jun N-terminal kinase (JNK) and caspase-3 activities and enhanced myocyte apoptosis and fibrosis, whereas replacement of IGF-1 or JNK inhibitor restored them
Henrotin et al., Osteoarthritis Cartilage 2010 (Inflammation...) : Curcumin blocks IL-1beta induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3
Li et al., Pain 2009 (Complex Regional Pain Syndromes...) : Using this model we observed that : ( 1 ) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, ( 2 ) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1 , and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, ( 3 ) LY303870, an NK1 receptor antagonist, effectively blocked fracture induced up-regulation of activated inflammasome components and cytokines, ( 4 ) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and ( 5 ) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture induced hindpaw mechanical allodynia
Clarke et al., Circ Res 2010 (Hyperlipidemias...) : In contrast, secondary necrotic VSMCs release both IL-1alpha and caspase activated IL-1beta , augmenting IL-6 and MCP-1 production
Guma et al., Arthritis Rheum 2009 (Arthritis, Experimental...) : The production of IL-1beta by neutrophils and mast cells is not exclusively dependent on caspase 1, and other proteases can compensate for the loss of caspase 1 in vivo
Auerbuch et al., PLoS Pathog 2009 (Yersinia pseudotuberculosis Infections) : However, caspase-1 was required for secretion of the inflammatory cytokine IL-1beta in response to T3SS positive Y. pseudotuberculosis
Meixenberger et al., J Immunol 2010 : RNA interference and inhibitor experiments in human PBMCs as well as experiments in Nlrp3 and Rip2 knockout bone marrow derived macrophages demonstrated that the Listeria induced IL-1beta release was dependent on ASC, caspase-1 , and NLRP3, whereas NOD2, Rip2, NLRP1, NLRP6, NLRP12, NLRC4, and AIM2 appeared to be dispensable
Imamura et al., J Immunol 2010 (Shock, Septic) : Interestingly, the NOD of human PYNOD was sufficient to inhibit caspase-1 mediated IL-1beta secretion, whereas its pyrin domain was sufficient to inhibit ASC mediated NF-kappaB activation and apoptosis and to reduce ASC 's ability to promote caspase-1 mediated IL-1beta production
Bauer et al., Gut 2010 (Colitis...) : Macrophages incubated with DSS in vitro secreted high levels of IL-1beta in a caspase-1 dependent manner
Dinarello et al., Expert Rev Clin Immunol 2005 : IL-18 is a member of the IL-1 family ; IL-1beta and IL-18 are closely related, and both require the intracellular cysteine protease caspase-1 for biologic activity
Zitta et al., Biochem Biophys Res Commun 2010 (Myocardial Infarction) : Gene expression of caspase-3 was increased by IL-1beta ( P < 0.05 vs. control ; 100ng/ml ; 3h ), and pro-caspase-3 but not active caspase was detected in lysates of pig heart cells by Western blotting
Kotrange et al., J Leukoc Biol 2011 (Burkholderia Infections) : Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1 dependent IL-1beta production in macrophages
Ghayur et al., Nature 1997 : A selective caspase-1 inhibitor blocks both lipopolysaccharide induced IL-1beta and IFN-gamma production from human mononuclear cells
Schumann et al., Blood 1998 : Taken together, these results show that LPS moderately activates caspase-1 and that caspase-1 activation contributes to LPS induction of IL-1 beta secretion
Johnson et al., Gene 1998 : However, the pattern of mRNA expression is consistent with a requirement for caspase-1 mediated IL-1beta production in chicken immune tissues