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CTNNB1 — DKK3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNNB1 → DKK3 (decreases, DKK3 Activity) Yue et al., Carcinogenesis 2008*
  Evidence: We found that Dickkopf (Dkk)-3, a member of Dkk family of Wnt antagonists, is frequently inactivated in lung cancer and plays a role in suppressing lung cancer cell growth through inhibition of beta-catenin/T-cell factor (TCF)-4 signaling. Dkk3 is the only Dkk family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of Dkk3 was correlated with tumor progression and expression of nucl...

Text-mined interactions from Literome

Koppen et al., Cancer Lett 2007 (Neuroblastoma) : Surprisingly, DKK1 expression did not inhibit the canonical wnt/beta-catenin signalling, suggesting a role of DKK1 in an alternative route of the wnt pathway
Yue et al., Carcinogenesis 2008 (Lung Neoplasms) : Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer ... Ectopic expression of Dkk3 in lung cancer cells with Dkk3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1
Wang et al., Mol Cell Biol 2008 : Reduction of DKK3 in control cells with a short hairpin RNA ( shRNA ) increases Notch and beta-catenin/TCF activation, whereas reduction of PLF1 with a shRNA in Msi1 expressing cells inhibits these pathways
Lee et al., Int J Cancer 2009 (Cell Transformation, Neoplastic...) : The stable expression of Dkk3 blocks the nuclear translocation of beta-catenin , resulting in downregulation of its downstream targets ( VEGF and cylcin D ), whereas knockdown of Dkk3 abrogates this blocking