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IL6 — SOS1

Pathways - manually collected, often from reviews:

• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family complex (GRB2-SOS1-GAB1_GAB2) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
  Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
  Evidence: mutant phenotype, physical interaction

Text-mined interactions from Literome

Ogata et al., J Immunol 1997 (Multiple Myeloma) : In contrast, IL-6 induced phosphorylation of Shc and its association with Sos1 , as well as phosphorylation of MAPK, only in MM cells and B9 cells that proliferated in response to IL-6
Ogata et al., Clin Cancer Res 1997 (Multiple Myeloma) : However, Grb2 is not associated with Sos1, and neither Grb2-to-Sos1 binding nor Sos1 phosphorylation is triggered by IL-6 in OCI-My5 MM cells ... On the other hand, Grb2 and Sos1 are associated constitutively in U266 and RPMI8226 MM cells, but phosphorylation of Sos1 is not induced by IL-6