◀ Back to EPHB2

EPHB2 — LCK

Pathways - manually collected, often from reviews:

• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) → FAP1 (PTPN13) (modification, collaborate) Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Palmer et al., Mol Cell 2002
  Evidence: assay
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Palmer et al., Mol Cell 2002
  Evidence: assay

Text-mined interactions from Literome

Dong et al., PloS one 2010 : TCR stimulation led to the co-precipitation of Lck with the transmembrane adaptor protein LAT ( linker for activation of T cells ), Erk mediated phosphorylation of Lck and no detectable dephosphorylation of Lck inhibitory tyrosine
Pan et al., Blood 2012 (HIV Infections) : Instead, Nef triggers Lck dependent activation of TGN associated Ras-Erk signaling to promote the production of the T lymphocyte survival factor IL-2 and to enhance virus spread