Gene interactions and pathways from curated databases and text-mining
PIK3CA: top 25 interacting genes (chr3:178866310-178952497)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only PIK3CA-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with PIK3CA, not among the Top 25
Other genes interacting with PIK3CA. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

EGF ▸ RAC1 ▸ EGFR ▸ IL6 ▸ NOS3 ▸ TNF ▸ MMP9 ▸
LEP ▸ IRS1 ▸ PTGS2 ▸ PI3 ▸ IL8 ▸ HMOX1 ▸ ANXA6 ▸
FOXO3 ▸ CASP3 ▸ IRF6 ▸ CASP9 ▸ CASP1 ▸ CASP14 ▸ CASP16 ▸
CASP12 ▸ CASP7 ▸ BCL2 ▸ CASP5 ▸ BCR ▸ CASP4 ▸ CASP6 ▸
CASP8 ▸ SRC ▸ CASP2 ▸ CASP10 ▸ GSK3B ▸ HIF1A ▸ HGF ▸
IL12A ▸ JUN ▸ IL12B ▸ IL2 ▸ IL10 ▸ NOS2 ▸ FOXO1 ▸
CCND1 ▸ MLST8 ▸ TLR4 ▸ RAC2 ▸ STAT3 ▸ CD28 ▸ NGF ▸
FGF2 ▸ KRAS ▸ CTNNB1 ▸ TLR2 ▸ IRS2 ▸ PTPN11 ▸ RAC3 ▸
NOX1 ▸ NOX3 ▸ MMP2 ▸ BDNF ▸ NOX4 ▸ NOX5 ▸ CBFA2T2 ▸
ESR1 ▸ TP53 ▸ RAF1 ▸ ARHGEF7 ▸ CREB1 ▸ CREB5 ▸ IL1B ▸
MAP2K1 ▸ CRK ▸ RHOA ▸ CREB3 ▸ HRAS ▸ CDC42 ▸ JAK2 ▸
RPTOR ▸ CD79A ▸ GRAP2 ▸ PRKAB1 ▸ IGF2 ▸ CD79B ▸ PRKAA2 ▸
PRKAG1 ▸ PRKAG2 ▸ PRKAA1 ▸ PRKAB2 ▸ CDKN1A ▸ BMP2 ▸ PRKAR1B ▸
MCL1 ▸ HSPG2 ▸ PRKACB ▸ MMP14 ▸ IFI27 ▸ PRKAR1A ▸ GAB1 ▸
PRKAR2A ▸ CBL ▸ PRKACG ▸ PRKAR2B ▸ TLR5 ▸ SMAD2 ▸ BCL10 ▸
SLC25A16 ▸ FOS ▸ SETD2 ▸ RAD50 ▸ PLCG1 ▸ STAT1 ▸ SLC2A4 ▸
FAS ▸ PARP1 ▸ PDGFB ▸ IFNG ▸ ACD ▸ MMP10 ▸ POT1 ▸
IL4 ▸ PIK3CB ▸ TERF2 ▸ RPS6KB1 ▸ PHKA2 ▸ TCF3 ▸ PDGFRB ▸
TINF2 ▸ TCF4 ▸ PIK3R1 ▸ TCF20 ▸ IGF1R ▸ XRCC6 ▸ TCF15 ▸
TCF23 ▸ XRCC5 ▸ PIK3CD ▸ JAK1 ▸ ANGPT2 ▸ TCF12 ▸ CXCL12 ▸
XIAP ▸ TCF25 ▸ TMED7 ▸ PRKCA ▸ TGFB1 ▸ TCF19 ▸ MRE11A ▸
TCF7 ▸ ESR2 ▸ MMP7 ▸ TLR3 ▸ BAX ▸ MMP12 ▸ IL17A ▸
SYK ▸ TCF21 ▸ TCF24 ▸ PTK2 ▸ AHSA1 ▸ TERF2IP ▸ MMP13 ▸
IL3 ▸ TERF1 ▸ PLD2 ▸ SLC2A1 ▸ MMP1 ▸ MMP11 ▸ ZGLP1 ▸
MMP21 ▸ TLR6 ▸ MMP17 ▸ MYD88 ▸ ILK ▸ PLAU ▸ ICAM1 ▸
FOXO4 ▸ VCAM1 ▸ MMP24 ▸ MMP8 ▸ MMP25 ▸ MMP28 ▸ JAK3 ▸
CTGF ▸ MMP27 ▸ TLR10 ▸ MMP20 ▸ MMP26 ▸ NOS1 ▸ RAB5A ▸
SREBF1 ▸ TLR7 ▸ GJA1 ▸ FOXO6 ▸ MYLIP ▸ PRL ▸ TLR1 ▸
TLR9 ▸ TLR8 ▸ SP1 ▸ MMP16 ▸ IKBKG ▸ EIF4EBP1 ▸ MMP19 ▸
MMP15 ▸ MMP3 ▸ PTK6 ▸ STK16 ▸ KITLG ▸ ECM2 ▸ LCK ▸
STK25 ▸ STK33 ▸ IL7 ▸ STK19 ▸ PDLIM7 ▸ SLC22A3 ▸ PLA2G1B ▸
CDH1 ▸ HSP90AA1 ▸ STK24 ▸ EPO ▸ PIP ▸ BCL9 ▸ GYS2 ▸
RICTOR ▸ STK3 ▸ NFKBIA ▸ IL13 ▸ STK31 ▸ SMAD4 ▸ HRG ▸
CSF1 ▸ WNK1 ▸ STK4 ▸ NTRK1 ▸ SMAD1 ▸ LPA ▸ STK36 ▸
GDNF ▸ FYN ▸ STK10 ▸ STK39 ▸ STK40 ▸ STK11 ▸ INSR ▸
PLCG2 ▸ TGFB2 ▸ SYT1 ▸ ECM1 ▸ IL18 ▸ GRB2 ▸ PTK7 ▸
BCL5 ▸ CA2 ▸ STK38 ▸ GYS1 ▸ MET ▸ CXCL11 ▸ STK35 ▸
FOSL1 ▸ FGF21 ▸ SERPINE1 ▸ BTK ▸ SMAD5 ▸ BCL6 ▸ BCL3 ▸
NANOG ▸ IL5 ▸ ODC1 ▸ FGF22 ▸ IL11 ▸ HDAC2 ▸ IL24 ▸
ATP5O ▸ CAV3 ▸ F2RL1 ▸ FGF4 ▸ FGF20 ▸ TNFSF10 ▸ CD4 ▸
CAT ▸ CXCR4 ▸ LGALS3 ▸ FGF13 ▸ RLN3 ▸ IL32 ▸ TAT ▸
FGF12 ▸ FGF17 ▸ PBK ▸ FGF9 ▸ NA ▸ SMAD6 ▸ IL1A ▸
CDC73 ▸ SMAD9 ▸ FASLG ▸ CTLA4 ▸ HDAC1 ▸ PLD1 ▸ PAK2 ▸
TPO ▸ ADORA3 ▸ PPARG ▸ CCND2 ▸ FGF6 ▸ RBBP4 ▸ PLA2G4A ▸
BAD ▸ PLD4 ▸ FGF8 ▸ ABCB1 ▸ RUNX2 ▸ CXCL9 ▸ FGF3 ▸
FGF23 ▸ ADORA1 ▸ TNFSF13B ▸ FGF19 ▸ ITGB1 ▸ RLN2 ▸ WNT4 ▸
GPR15 ▸ RBBP7 ▸ KIT ▸ AKT1S1 ▸ FGF18 ▸ CAV2 ▸ GAB2 ▸
GSK3A ▸ FGF11 ▸ PDE3B ▸ PDK1 ▸ SHC1 ▸ STAT6 ▸ RNF19A ▸
SGK3 ▸ PIK3IP1 ▸ NPY4R ▸ EHMT1 ▸ SGK1 ▸ BRAF ▸ PLD6 ▸
PPP1R3A ▸ VAV1 ▸ PCNA ▸ FGF10 ▸ AR ▸ CALM3 ▸ SOAT1 ▸
SMAD3 ▸ CYP19A1 ▸ PLD3 ▸ PIK3CG ▸ HSPB1 ▸ SMAD7 ▸ CAV1 ▸
HDAC3 ▸ BPNT1 ▸ CCNG1 ▸ FGF5 ▸ EGR1 ▸ FGF1 ▸ FGF7 ▸
PAK1 ▸ FGF16 ▸ PLD5 ▸ BMP6 ▸ FGF14 ▸ SPP1 ▸ MYC ▸
ERBB2 ▸ RLN1 ▸ NTRK2 ▸ ARAF ▸ BRCA1 ▸ LYN ▸ UCN ▸
IL15 ▸ CD86 ▸ GPR176 ▸ C1orf228 ▸ GPR126 ▸ GPR50 ▸ BMP1 ▸
LDLR ▸ GPR87 ▸ CPOX ▸ SLPI ▸ SIRT1 ▸ PAK4 ▸ ITGA6 ▸
IL26 ▸ BMP7 ▸ PGP ▸ E2F1 ▸ NCF4 ▸ BSG ▸ ITIH4 ▸
GPR3 ▸ IGFBP3 ▸ ADRBK1 ▸ CDC34 ▸ DDIT3 ▸ TFRC ▸ GPR128 ▸
IRS4 ▸ GPR162 ▸ CDC7 ▸ GPR173 ▸ GPR56 ▸ CD2 ▸ GPR115 ▸
MYOG ▸ NOTCH1 ▸ CDK5 ▸ GDF15 ▸ ICOS ▸ GPR149 ▸ CCK ▸
GPER1 ▸ IL1RN ▸ LIF ▸ GPR148 ▸ GPR19 ▸ CALM2 ▸ RBL2 ▸
ADAM12 ▸ GPR112 ▸ WNT1 ▸ IRF1 ▸ GNE ▸ IL33 ▸ WNT16 ▸
GPR82 ▸ IL27 ▸ NRG1 ▸ TGFB3 ▸ NTRK3 ▸ SST ▸ PKD1 ▸
GPR146 ▸ GPR22 ▸ GPR161 ▸ PAK7 ▸ GPR97 ▸ GPR124 ▸ IL6ST ▸
GPR160 ▸ GPR84 ▸ CHUK ▸ GPR171 ▸ GPR116 ▸ GPR21 ▸ SLC9A1 ▸
GPR55 ▸ UVRAG ▸ HMGB1 ▸ GPR32 ▸ GPR68 ▸ CSE ▸ NCF1 ▸
CDC40 ▸ BMP10 ▸ CCL2 ▸ GPR26 ▸ DAB2IP ▸ GPR180 ▸ GPR133 ▸
PDX1 ▸ GPR143 ▸ TBL1XR1 ▸ ARSK ▸ CD38 ▸ CDC20 ▸ TYR ▸
ERBB4 ▸ GPR83 ▸ TSC2 ▸ CDC16 ▸ GAPDH ▸ CDC27 ▸ CXCL10 ▸
CDC26 ▸ CCDC88A ▸ GPR45 ▸ GPR31 ▸ RAE1 ▸ MSC ▸ GPR20 ▸
GPR107 ▸ CDC6 ▸ GPR182 ▸ SKP2 ▸ GPR42 ▸ MDM2 ▸ GPR18 ▸
GPR25 ▸ SNAI2 ▸ AGTR2 ▸ GPR135 ▸ NTF3 ▸ MAP3K7 ▸ GPR78 ▸
BMP15 ▸ GPR12 ▸ GPR27 ▸ CSF2 ▸ FGFR2 ▸ LTB ▸ GPR39 ▸
GPR174 ▸ GPR17 ▸ ANG ▸ GPR114 ▸ IL20 ▸ GPR62 ▸ GPR113 ▸
GPR152 ▸ GPR64 ▸ NFAT5 ▸ ITGA5 ▸ BMP4 ▸ ABL1 ▸ TBL1X ▸
BIRC2 ▸ GPR153 ▸ PRKCZ ▸ WNT3 ▸ WNT2 ▸ MUC8 ▸ GPR88 ▸
CDH5 ▸ CORO2A ▸ GRP ▸ GPR158 ▸ MUC1 ▸ SOCS3 ▸ PREX1 ▸
PSEN1 ▸ IL21 ▸ MOK ▸ GPR132 ▸ GPR79 ▸ GPR141 ▸ CEBPA ▸
CHKA ▸ ITGB4 ▸ MAP3K5 ▸ DAB1 ▸ HBEGF ▸ GPR137 ▸ GPR85 ▸
RHEB ▸ FGR ▸ IL34 ▸ IL31 ▸ GPR108 ▸ CX3CL1 ▸ TRNAE1 ▸
GPR33 ▸ GTPBP1 ▸ GPR156 ▸ IL16 ▸ IL9 ▸ GPR98 ▸ GPR157 ▸
PAK3 ▸ GPR4 ▸ GPR119 ▸ CD19 ▸ CDC23 ▸ CDC37 ▸ GPR52 ▸
IFNB1 ▸ RPL17 ▸ NFE2L2 ▸ GPR75 ▸ BMP3 ▸ GPR139 ▸ GPR1 ▸
GPR65 ▸ IL25 ▸ PTH ▸ PKD2 ▸ MYCN ▸ GPR142 ▸ GPR110 ▸
WNT11 ▸ GPR179 ▸ IL22 ▸ CALM1 ▸ IKBKB ▸ PRDX2 ▸ WNT6 ▸
CDC123 ▸ PTGES ▸ PLEK ▸ PTTG1 ▸ IL19 ▸ NCOR1 ▸ CEBPB ▸
IL37 ▸ GPR144 ▸ FOXP3 ▸ GPR151 ▸ GPR125 ▸ GPR36 ▸ PLAT ▸
GPR150 ▸ PKD3 ▸ GPR155 ▸ PAK6 ▸ GPR101 ▸ VEGFC ▸ SMN1 ▸
CDC45 ▸ MT3 ▸ GPR123 ▸ GPR63 ▸ GPR35 ▸ GPR111 ▸ GPR37 ▸
GPR183 ▸ GPR61 ▸ BMP5 ▸ GPR6 ▸ AQP3 ▸ CD14 ▸ NM ▸
GPR34 ▸ GPS2 ▸ PTBP1 ▸ PIP4K2C ▸ RPLP1 ▸ BASP1 ▸ STAT5B ▸
CD80 ▸ RUVBL1 ▸ YWHAG ▸ PLCD1 ▸ IGF2BP3 ▸ FCER1G ▸ SHC3 ▸
GNB3 ▸ GNB1 ▸ FBL ▸ CD247 ▸ PPP1CA ▸ LGALS3BP ▸ PHLDA1 ▸
IGLC3 ▸ EFNA1 ▸ ILF3 ▸ EIF5AL1 ▸ ITGAV ▸ S100A10 ▸ MYH10 ▸
HIST2H2BF ▸ GH1 ▸ IL12RB1 ▸ GNG4 ▸ HIST2H2BE ▸ HNRNPC ▸ INPP5B ▸
FLT3 ▸ PIP4K2A ▸ YBX3 ▸ ANGPT1 ▸ IL23A ▸ KLRD1 ▸ IGF2BP1 ▸
VEGF ▸ PIK3R4 ▸ HIST1H4A ▸ PCBP1 ▸ MATR3 ▸ PLCZ1 ▸ PRKRA ▸
FCGR1A ▸ IL1R1 ▸ HIST2H2AC ▸ ZAP70 ▸ IL23R ▸ WDR5 ▸ EPS8 ▸
HIST1H2AD ▸ PABPN1 ▸ PCID2 ▸ SLC9A3R1 ▸ HLA-DRA ▸ ITIH1 ▸ RPSA ▸
STAU1 ▸ EEF1A2 ▸ TRIM21 ▸ MRPS22 ▸ PIK3C2G ▸ YWHAE ▸ ZMYM2 ▸
GNGT1 ▸ SEMG2 ▸ EPB41L1 ▸ SLC25A5 ▸ WDR6 ▸ HNRNPA1 ▸ SH3KBP1 ▸
ERH ▸ HIST1H2BL ▸ FGFR1OP2 ▸ TUBB ▸ GSN ▸ GNA11 ▸ HNRNPH3 ▸
PIK3C2A ▸ EDG1 ▸ ALYREF ▸ GFRA1 ▸ HIST1H1T ▸ IL2RG ▸ RASGRP3 ▸
ELAVL1 ▸ GNG10 ▸ MRPS14 ▸ APLP2 ▸ PPIA ▸ SPTA1 ▸ MOV10 ▸
APPL1 ▸ HNRNPUL1 ▸ ACTA2 ▸ GABRB1 ▸ SEMG1 ▸ LAT ▸ EIF5A ▸
FLNB ▸ NGFB ▸ GNG3 ▸ IGHG1 ▸ MIF ▸ RPL22 ▸ EEF1A1 ▸
SLC25A31 ▸ HIST1H2BJ ▸ HIST1H2AG ▸ ILF2 ▸ SHANK3 ▸ RPS11 ▸ RPS24 ▸
HNRNPH2 ▸ HNRNPD ▸ IL1RAP ▸ UBTF ▸ IL4R ▸ FCGR3B ▸ FCGR3A ▸
CSF1R ▸ VARS2 ▸ MYO1C ▸ HNRNPAB ▸ PTMA ▸ DNAJB6 ▸ FTL ▸
EEF2 ▸ KLB ▸ JUP ▸ PTPN1 ▸ RPLP0P6 ▸ MRPS34 ▸ SOS1 ▸
MYH14 ▸ PPP1CC ▸ TIMM50 ▸ GNB5 ▸ HIST3H2A ▸ PGAM1 ▸ PGR ▸
NBPF8 ▸ AP1M2 ▸ EIF2AK1 ▸ GNG11 ▸ TPI1 ▸ VLDLR ▸ UBC ▸
PABPC4 ▸ AMPH ▸ DDX5 ▸ SH2D2A ▸ DGKZ ▸ TREM2 ▸ MRPS26 ▸
TUBA1C ▸ FLT1 ▸ RPS5 ▸ HNRNPA0 ▸ IGF2BP2 ▸ HIST1H2BM ▸ HNRNPA2B1 ▸
YWHAH ▸ PLCB3 ▸ GNAI3 ▸ RPL23 ▸ HIST1H2AC ▸ PLCD4 ▸ AMBP ▸
HIST1H2AE ▸ PIP5K1C ▸ RRAS2 ▸ HIST3H2BB ▸ DDX3X ▸ F11R ▸ MYL6 ▸
PDE4D ▸ YWHAQ ▸ MASP1 ▸ VAV3 ▸ PIK3R5 ▸ MRPS27 ▸ PIP5K1B ▸
ITGB2 ▸ VAV2 ▸ FGA ▸ TUBB4B ▸ ATPIF1 ▸ LRPPRC ▸ SGK2 ▸
GNA15 ▸ HSP90AB1 ▸ SYNJ2 ▸ ARHGEF1 ▸ SQSTM1 ▸ FGFR1OP ▸ MRPS18B ▸
RPS4X ▸ HIST1H2AJ ▸ RHOG ▸ MS4A2 ▸ NPHS2 ▸ RPL28 ▸ IGLC6 ▸
TYROBP ▸ GNB2 ▸ PIK3AP1 ▸ RPS3 ▸ NEDD9 ▸ KLRK1 ▸ IL3RA ▸
ADAR ▸ IGLC1 ▸ FUS ▸ IGLC2 ▸ IGKV4-1 ▸ KIRREL ▸ PIK3R2 ▸
CCAR2 ▸ PGAM4 ▸ ITK ▸ MARCKS ▸ NR3C1 ▸ B2M ▸ CNTRL ▸
MYH9 ▸ Il7r ▸ MDH2 ▸ ABI1 ▸ KL ▸ ANXA2 ▸ CBLC ▸
MRPS25 ▸ RTCB ▸ SYNJ1 ▸ INPP5E ▸ POTEKP ▸ HNRNPA3 ▸ HNRNPR ▸
HRNR ▸ PGAM2 ▸ RPS18 ▸ CBLB ▸ HLA-B ▸ HLA-E ▸ GNG8 ▸
CCT5 ▸ CPSF1 ▸ TRAT1 ▸ ACTG2 ▸ CUX1 ▸ CANX ▸ TUBA1A ▸
RPLP0 ▸ OCRL ▸ TRB@ ▸ MRPL12 ▸ INSRR ▸ PRKCI ▸ TEK ▸
GNG12 ▸ SHC2 ▸ HIST1H2AH ▸ PLCB2 ▸ PDPK1 ▸ NRAS ▸ PIK3C2B ▸
RPS12 ▸ CD3Z ▸ EIF5A2 ▸ H2AFJ ▸ CALR ▸ CTNNA1 ▸ GNG13 ▸
FGG ▸ GNG2 ▸ DNM1L ▸ NPM1 ▸ HNRNPK ▸ TIAM2 ▸ GHR ▸
DDX3Y ▸ CSF2RB ▸ SLC25A4 ▸ CRKL ▸ XRN2 ▸ HNRNPU ▸ HIST2H2AA3 ▸
RBMX ▸ HIST1H2AB ▸ RALY ▸ YWHAZ ▸ GNA14 ▸ RPS10 ▸ SNRPF ▸
HIST1H2BD ▸ ATP5B ▸ HIST1H2BK ▸ IGLC7 ▸ MRAS ▸ PLCE1 ▸ ENY2 ▸
HNRNPH1 ▸ DHX15 ▸ PPP1CB ▸ ATXN2L ▸ PLCB1 ▸ NEFH ▸ PCBP3 ▸
MRPS23 ▸ HIST1H2BO ▸ PLCB4 ▸ EPHB1 ▸ PIK3R3 ▸ TXK ▸ EFNB2 ▸
FGB ▸ SSR1 ▸ CSF2RA ▸ HIST1H1A ▸ DHX30 ▸ EEF1A1P5 ▸ INS-IGF2 ▸
PABPC1 ▸ IL5RA ▸ DNAJB11 ▸ NPHS1 ▸ ATP1A1 ▸ TRIM24 ▸ SMO ▸
IL2RB ▸ HNRNPDL ▸ ALDOA ▸ LAT2 ▸ HNRNPL ▸ IGHE ▸ PAICS ▸
PGF ▸ UPF1 ▸ PTCD3 ▸ EPHB4 ▸ LDHB ▸ PCBP2 ▸ H2BFS ▸
SLC25A3 ▸ HCST ▸ DHX9 ▸ GNGT2 ▸ HIST1H2BH ▸ PIK3R6 ▸ NKRF ▸
YES1 ▸ UFD1L ▸ PLCD3 ▸ HLA-A ▸ SNRPD3 ▸ BCAR1 ▸ MRPS17 ▸
GNG5 ▸ SYNCRIP ▸ GNAO1 ▸ KLRC2 ▸ UNC5B ▸ GNAI1 ▸ IFNGR1 ▸
RUVBL2 ▸ PDGFRA ▸ AIFM1 ▸ GRIN2B ▸ ADAP1 ▸ MAP2K2 ▸ RPS20 ▸
GNG7 ▸ ATR ▸ RASD2 ▸ HNRNPF ▸ IGHG4 ▸ KHDRBS1 ▸ CKB ▸
GNAQ ▸ IGKV1-5 ▸ HIST1H2BN ▸ TRA@ ▸ DDX17 ▸ HIST2H2AA4 ▸ FRS2 ▸
GNAI2 ▸ HLA-DRB1 ▸ PON2 ▸ HIST1H2BB ▸ PGK1 ▸ PIP5K1A ▸ ACTBL2 ▸
DLG1 ▸ FES ▸ FCER1A ▸ ATP1A3 ▸ GNB4 ▸ TUBA4A ▸ FIGF ▸
IGHG3 ▸ ENO1 ▸ ITGB3 ▸ DNAJA1 ▸ RPS2 ▸ C14orf166 ▸ PRDX6 ▸
IGHG2 ▸ MRPS28 ▸ IGKC ▸
Data information
Please see the Gene Interactions Track Manual.