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MYLIP — TLR2

Text-mined interactions from Literome

Dai et al., Blood 2008 : We found that miR-146a , a negative regulator of Toll-like receptor ( TLR ) signaling, was decreased in freshly isolated splenic lymphocytes from estrogen treated mice compared with placebo controls
Sheedy et al., Ann Rheum Dis 2008 (Arthritis, Rheumatoid...) : Both have multiple targets, with miR-146 inhibiting TLR signalling and miR-155 regulating Th1 cells and also, interestingly, positively regulating mRNA for TNFalpha
Bazzoni et al., Proc Natl Acad Sci U S A 2009 (Inflammation) : miR-9 is also induced by TLR2 and TLR7/8 agonists and by the proinflammatory cytokines TNF-alpha and IL-1beta, but not by IFNgamma
Liu et al., Proc Natl Acad Sci U S A 2009 (Inflammation) : These data demonstrate a negative-feedback loop in which TLR stimulation induces miR-147 to prevent excessive inflammatory responses
Cho et al., J Cell Physiol 2010 (Calcinosis) : Overexpression of miR-146a induced the inhibition of IRAK1 expression and inhibited basal and TNF-alpha- and TLR ligand induced osteogenic differentiation
Case et al., Exp Lung Res 2011 (Pneumonia) : The goal of this study was to determine if in vivo, miR-21 regulates a TLR2 agonist induced lung inflammatory response ... These results, for the first time, suggest an in vivo role of miR-21 in suppressing TLR2 signaling, and further support that IL-13 can up-regulate miR-21 in human airway epithelial cells
Philippe et al., J Immunol 2012 (Arthritis, Rheumatoid) : TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes
Tarassishin et al., Glia 2011 : Astrocyte miR-155/miR155* were induced by cytokines and TLR ligands with a distinct hierarchy and involved in proinflammatory cytokine gene induction by targeting suppressor of cytokine signaling 1, a negative regulator of cytokine signaling and potentially other factors
Ghorpade et al., Mol Cell Biol 2012 : We here demonstrate that M. bovis BCG triggers Toll-like receptor 2 (TLR2) dependent microRNA-155 (miR-155) expression, which involves signaling cross talk among phosphatidylinositol 3-kinase (PI3K), protein kinase Cd ( PKCd ), and mitogen activated protein kinases ( MAPKs ) and recruitment of NF-?B and c-ETS to miR-155 promoter
Koch et al., Proc Natl Acad Sci U S A 2012 : miR-155 is regulated by Toll-like receptor ( TLR ) ligands in monocyte derived cells and has been shown to be induced in macrophages during H. pylori infection
Nahid et al., J Immunol 2013 : During bacterial infection, PGN mediated TLR2 signaling induces miR-132/-212 to downregulate IRAK4, an early component in the MyD88 dependent pathway, whereas LPS/TLR4 induced miR-146a downregulates downstream components of the same MyD88 dependent pathway
Quinn et al., PloS one 2013 : The aim of this study was to assess the role of miR-146a in the TLR2 signaling and development of bacterial lipoprotein (BLP) self-tolerance and cross-tolerance to bacteria