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CPOX — MRXS5
Text-mined interactions from Literome
Jeng et al., Carcinogenesis 2000
:
PGE ( 2 ) exhibited little effect on the growth of GK at concentrations ranging from 100-1000 pg/ml. Stimulating GK production of
PGs by AN extract could be
due to induction of
cyclooxygenase-2 (COX-2) mRNA expression and protein production
Abassi et al., American journal of physiology. Renal physiology 2001
(Disease Models, Animal...) :
The generation of
PGs from arachidonic acid is
mediated by
cyclooxygenase (COX) , which consists of a constitutive ( COX-1 ) and an inducible ( COX-2 ) isoform
Dicker et al., Am J Clin Oncol 2003
(Neoplasms) :
Nonsteroidal antiinflammatory drugs ( NSAIDs ) inhibit
COX mediated synthesis of
PGs
Takeeda et al., J Physiol Pharmacol 2004
(Body Weight...) :
Endogenous prostaglandins (PGs) are involved in adaptive gastric protection against acute injury, and
cyclooxygenase (COX)-1 is
responsible for the production of
PGs in this phenomenon
Amir et al., Pharmazie 2005
(Neoplasms...) :
Cyclooxygenase-2 (COX-2) is an enzyme induced by inflammatory and mitogenic stimuli and
results in enhanced synthesis of
PGs in inflamed and neoplastic tissues
Murata et al., Proc Natl Acad Sci U S A 2008
(Corneal Neovascularization...) :
Although
COX dependent production of
prostaglandins (PGs) is known to be crucial for tumor angiogenesis and growth, the role of PGD ( 2 ) remains virtually unknown
Twarock et al., Br J Pharmacol 2009
(Carcinoma, Squamous Cell...) :
Furthermore,
COX2 dependent synthesis of
prostaglandins (PGs) stimulates HA synthase-1 (HAS1) and HAS2 mRNA expression, together with HA synthesis via the cAMP/protein kinase A pathway in vascular smooth muscle cells