◀ Back to SREBF1

PPARGC1A — SREBF1

Text-mined interactions from Literome

Oberkofler et al., Biochem J 2004 (Carcinoma, Hepatocellular...) : Ectopic overexpression of PGC-1alpha in HepG2 cells enhanced basal SREBP-1c and, to a lesser extent, -1a mRNA expression, but only SREBP-1c expression was augmented further in an LXR/RXR ( retinoic X receptor ) -dependent fashion, thereby inducing mRNA abundance levels of SREBP-1c target genes, fatty acid synthase and acetyl-CoA carboxylase ... These results indicate that PGC-1alpha contributes to the regulation of SREBP-1 gene expression, and can restore the SREBP-1 isoform expression pattern of HepG2 cells to that of human liver
Ponugoti et al., Mol Endocrinol 2007 : SREBP-1c also inhibited PGC-1alpha-coactivation of estrogen receptor, constitutive androstane receptor, pregnane X receptor, and farnesoid X receptor, implying inhibition of HNF-4 by SREBP-1c could extend to other nuclear receptors
Hao et al., Biochim Biophys Acta 2010 : ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes ... We demonstrate that ADD1/SREBP1c is a powerful inducer of PGC1alpha expression via a conserved E box in the proximal promoter and that beta-adrenergic stimulation led to recruitment of ADD1/SREBP1c to this E box