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IGF1 — KISS1

Text-mined interactions from Literome

Luque et al., Endocrinology 2007 (Obesity) : Moreover, leptin, but not insulin or IGF-I , stimulated KiSS-1 mRNA expression in the mouse hypothalamic cell line N6
Hiney et al., Endocrinology 2009 : Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat ... Real-time PCR revealed that IGF-I induced ( P < 0.01 ) KiSS-1 gene expression at 6 h in a tissue fragment that contained both the anteroventral periventricular ( AVPV ) and arcuate (ARC) nuclei ... IGF-I stimulated ( P < 0.01 ) KiSS-1 gene expression in the AVPV nucleus at 6 h after injection, with no change observed in the ARC nucleus ... E2 appears to play an important permissive role because 1-d ovariectomized rats responded to IGF-I with increased ( P < 0.01 ) KiSS-1 expression, whereas, 20 d after ovariectomy, when the E2 levels had fallen below assay sensitivity, the IGF-I was unable to induce KiSS-1 expression ... Collectively, these data indicate that IGF-I is an activator of the KiSS-1 gene in the prepubertal female rat
Srivastava et al., Alcohol Clin Exp Res 2009 : As IGF-1 , in the presence of E ( 2 ), can induce expression of the KiSS-1 gene, we assessed the potential for ALC to alter IGF-1 signaling in the reproductive hypothalamus
Hiney et al., Neuroscience 2010 : IGF-1 can induce KiSS-1 gene expression as an early pubertal event ; however, the signaling pathway mediating this effect is not known ... IGF-1 stimulated ( P < 0.01 ) KiSS-1 gene expression in the AVPV nucleus at 6 h, but did not affect expression of the kisspeptin receptor, GPR54 ... While ALC did not alter basal expression of either gene, its dose dependently blocked IGF-1 induced KiSS-1 gene expression in the AVPV nucleus ... Our results indicate that the IGF-1 induction of KiSS-1 gene expression is mediated by Akt activation, and that ALC alters this important prepubertal action of IGF-1