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CXCL12 — ZAP70
Text-mined interactions from Literome
Ticchioni et al., Blood 2002
:
Furthermore,
CXCL12 induced time dependent phosphorylation of
ZAP-70 , Vav1, and extracellular signal regulated kinases ( ERKs ) ; the latter were reduced in the absence of functional ZAP-70
Lin et al., Mol Immunol 2010
(Inflammation) :
SDF-1 enhanced
Zap70 phosphorylation and also stimulated binding of talin and beta1 integrin activation
Messmer et al., Blood 2011
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Although significant differences in the expression or turnover of CXCR4 were not observed between ZAP-70 ( + ) and ZAP-70 ( - ) cell samples,
CXCL12 induced greater intracellular Ca ( 2+ ) flux and stronger and more prolonged phosphorylation of extracellular signal regulated kinase ( ERK ) and mitogen activated protein kinase/ERK kinase ( MEK ) in the
ZAP-70 ( + ) CLL cells
Kremer et al., J Immunol 2011
:
G alpha i2 and
ZAP-70 mediate RasGRP1 membrane localization and
activation of
SDF-1 induced T cell functions