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RAC1 — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ARF6-RAC1 → VEGFA (increases)
  Evidence: In ECs, VEGF stimulates ARF6 association with Rac1, which is cotemporaneous with Rac1 activation.
• Reactome Reaction: VEGFA → RAC1 (reaction) Brugnera et al., Nat Cell Biol 2002

Text-mined interactions from Literome

Soga et al., Exp Cell Res 2001 : VEGF signaling required Rac activation during chemotaxis, and Rac and Cdc42 were activated during haptotaxis on type I collagen
Ikeda et al., Circ Res 2005 (Ischemia) : In this study, we show that overexpression of dominant negative ARF6 [ ARF6 ( T27N ) ] almost completely inhibits VEGF induced Rac1 activation, ROS production, and VEGFR2 autophosphorylation in ECs
Dentelli et al., Oncogene 2005 (Neoplasm Invasiveness...) : Engagement of IL-3 receptor beta common ( IL-3R beta c ) contributes to both IL-3- and VEGF induced Rac1 activation, cell migration and in vitro tube-like structure formation as shown by the expression of the dominant negative IL-3R beta c construct ( Delta455 )
Saníger et al., J Cell Biochem 2006 : These findings indicate that Rho oncoprotein endogenously activated regulates VEGF expression through a transcriptional mechanism, and that the c-Jun kinase activity is a mediator in the expression of VEGF induced by Rac1 and Cdc42 oncoproteins, but not of that induced by RhoA
Lee et al., Clin Cancer Res 2006 (Carcinoma, Hepatocellular...) : Rac induced the transcriptional activation of VEGF by direct interaction with hypoxia-inducible factor-1alpha ( HIF-1alpha ) expression
Garrett et al., Exp Cell Res 2007 : VEGF induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2 ... The goal of this study was to identify the GEF responsible for activating Rac1 in response to VEGF stimulation ... We have found that VEGF stimulates biphasic activation of Rac1 and for these studies we focused on the peak of activation that occurs at 30 min. Inhibition of VEGFR-2 signaling blocks VEGF induced Rac1 activation ... Additionally, we show that depleting endothelial cells of endogenous Vav2 with siRNA prevents VEGF induced Rac1 activation
Miao et al., Arterioscler Thromb Vasc Biol 2008 : Moreover, D88N-Hsp90 abolished VEGF stimulated Rac activation and suppressed VEGF induced stress fiber formation
Yokomori et al., Liver Int 2009 : Rac1 activity increased progressively to 17 h in cells cultured without VEGF, but markedly increased at 7 h in the presence of VEGF
Peng et al., Acta Diabetol 2010 (Diabetic Nephropathies) : Using an integrated in vitro approach, we investigated whether the effect of VEGF on endothelial cell permeability involves Rac1 GTPase activation and tight junction disassembly
Miura et al., Exp Cell Res 2010 (Corneal Neovascularization) : Consistent with these observations, rhChM-I was found to significantly reduce the activity of Rac1/Cdc42 during cell spreading, and the VEGF-A induced Rac1 activity but not its basal activity in quiescent cells
Monaghan-Benson et al., Am J Pathol 2010 (Choroidal Neovascularization...) : We found that vascular endothelial growth factor induced the activation of Rac1 and of NADPH oxidase in cultured human choroidal endothelial cells ... Taken together, these results indicate that vascular endothelial growth factor activates Rac1 upstream from NADPH oxidase in human choroidal endothelial cells and increases generation of reactive oxygen species, contributing to choroidal neovascularization
Oshikawa et al., Am J Physiol Heart Circ Physiol 2012 (MAP Kinase Signaling System) : Depletion of endogenous p66Shc with short interfering RNA inhibits VEGF induced Rac1 activity and ROS production
Kearns et al., Am J Physiol Lung Cell Mol Physiol 2012 (Emphysema) : Our data show that the uptake of apoptotic cells by murine AMs and human monocyte derived macrophages is inhibited by depletion of VEGF and that VEGF activates Rac1
Zang et al., Cell Signal 2013 : VEGF-A stimulated extracellular-signal regulated kinase, Akt and Rac1 activities in the wild-type cells whereas no such responses were noted in the knockout cells
Ma et al., PloS one 2013 : Here, we determined that activated Rac1/Cdc42 in MCF-7 breast cancer cells could decrease p53 protein levels and increase VEGF secretion to promote proliferation and tube formation of human umbilical vein endothelial cells ( HUVECs )