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OPTN — TNF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Vittitow et al., Biochem Biophys Res Commun 2002
(Genetic Predisposition to Disease...) :
OPTN expression is also
induced 2.3-fold by
TNFalpha and 2.6-fold by prolonged DEX treatment
Zhu et al., Curr Biol 2007
(Glaucoma) :
Optineurin negatively
regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP
Sudhakar et al., PloS one 2009
:
NF-kappaB mediates
tumor necrosis factor alpha
induced expression of
optineurin , a negative regulator of NF-kappaB ...
TNFalpha induced
optineurin promoter activity was inhibited by expression of inhibitor of NF-kappaB ( IkappaBalpha ) super-repressor ... Blocking of NF-kappaB activation resulted in inhibition of
TNFalpha induced
optineurin gene expression
Sudhakar et al., Biochem Biophys Res Commun 2013
:
Previously we have shown that
tumor necrosis factor-a activates
optineurin promoter through NF-?B binding site in the core promoter ... The synergistic effect of these two transcription factors ( IRF-1 and NF-?B ) may be involved in cooperative
induction of
optineurin promoter by interferon-? and
tumor necrosis factor-a
Li et al., Mol Cell Biol 1998
:
Three major mRNA forms of
FIP-2 have been detected in multiple human tissues, and expression of the transcripts was
induced by
TNF-alpha treatment in a time dependent manner in two different cell lines ... These data suggest that
FIP-2 is one of the cellular targets for Ad E3-14.7K and that its mechanism of affecting cell death
involves the
TNF receptor, RIP, or a downstream molecule affected by either of these two molecules