◀ Back to PXN

PTK2B — PXN

Pathways - manually collected, often from reviews:

• KEGG Chemokine signaling pathway: PTK2B → PXN (protein-protein, binding/association)
• NCI Pathway Database CXCR4-mediated signaling events: CRK (CRK) → PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) (modification, collaborate)
  Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: RAP1B/GTP complex (RAP1B) → PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) (modification, activates)
  Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: Paxillin (PXN) → PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) (modification, collaborate)
  Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: Paxillin (PXN) → PYK2 (PTK2B) (modification, collaborate) Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) → PYK2 (PTK2B) (modification, collaborate) Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database LPA receptor mediated events: PYK2/RAFTK (PTK2B) → Paxillin (PXN) (modification, activates) Park et al., Cell Signal 2006*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → PYK2 (PTK2B) (modification, activates) Kanda et al., Biochem Biophys Res Commun 2003*, Rose et al., J Immunol 2003
  Evidence: mutant phenotype
• WikiPathways Chemokine signaling pathway: PTK2B → PXN (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTK2B — PXN (physical association, affinity chromatography technology) Ivankovic-Dikic et al., Nat Cell Biol 2000*
• IRef Biogrid Interaction: PTK2B — PXN (physical association, affinity chromatography technology) Hiregowdara et al., J Biol Chem 1997*
• IRef Biogrid Interaction: PTK2B — PXN (direct interaction, far western blotting) Hiregowdara et al., J Biol Chem 1997*
• IRef Biogrid Interaction: PTK2B — PXN (direct interaction, pull down) Matsuya et al., J Biol Chem 1998*
• IRef Biogrid Interaction: PTK2B — PXN (physical association, affinity chromatography technology) Matsuya et al., J Biol Chem 1998*
• IRef Biogrid Interaction: PTK2B — PXN (physical association, affinity chromatography technology) Anfosso et al., J Biol Chem 2001*
• MIPS CORUM ITGAV-ITGB3-PXN-PTK2b complex: ITGAV-ITGB3-PXN-PTK2b complex complex (ITGAV-ITGB3-PTK2B-PXN) Pfaff et al., J Cell Sci 2001*
• IRef Corum Interaction: Complex of ITGB3-ITGB3-ITGAV-ITGAV-PXN-PXN-PTK2B-PTK2B (association, affinity chromatography technology) Pfaff et al., J Cell Sci 2001*
• IRef Hprd Interaction: PXN — PTK2B (in vitro) Hiregowdara et al., J Biol Chem 1997*
• IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Ophid Interaction: PXN — PTK2B (aggregation, confirmational text mining) Hiregowdara et al., J Biol Chem 1997*
• IRef Ophid Interaction: PXN — PTK2B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lyons et al., J Biol Chem 2001 : Tyrosine phosphorylation of paxillin , which is greatly enhanced by CAKbeta overexpression, was dramatically reduced upon coexpression of PTP-PEST
Park et al., J Biol Chem 2004 : However, Src significantly enhanced RAFTK mediated paxillin phosphorylation, suggesting a key role for Src in RAFTK activation and phosphorylation of downstream substrates
Melendez et al., J Biol Chem 2004 : Wild-type or mutant paxillin protein accumulation in the cytoplasm has no overt effect upon cell structure, but paxillin accumulation prevents losses of myofibril organization as well as focal adhesion kinase, vinculin, and paxillin protein levels mediated by RAFTK