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CDC45 — CDK2

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDC45 → CDK2 (reaction) Kukimoto et al., Eur J Biochem 1999, Saha et al., J Biol Chem 1998
• Reactome Reaction: CDC45 → CDK2 (indirect_complex) Kukimoto et al., Eur J Biochem 1999, Saha et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDC45 — CDK2 (physical association, affinity chromatography technology) Alexandrow et al., J Cell Biol 2005*

Text-mined interactions from Literome

Heo et al., Curr Genet 1999 : Hence, SCC1/MCD1/RHC21 is positively regulated by the mitotic CDK , CDC28
Zou et al., Mol Cell Biol 2000 : Here we show that both Cdc45p and replication protein A (RPA) bind to Mcm2p at the G ( 1 ) -S transition in an S-CDK dependent manner
Bruck et al., J Biol Chem 2011 : Sld3 binds tightly to Cdc45 in the presence or absence of cyclin dependent kinase activity
Cocklin et al., PloS one 2011 : Cell division is controlled in part by the timely activation of the CDK , Cdc28 , through its association with G1 and G2 cyclins
Jallepalli et al., Genes Dev 1996 : Rum1 and Cdc18 link inhibition of cyclin dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe
Sutton et al., Genetics 1997 : The CAK1 gene encodes the major CDK activating kinase (CAK) in budding yeast and is required for activation of Cdc28p for cell cycle progression from G2 to M phase