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IL1B — NLRC4

Text-mined interactions from Literome

Franchi et al., Nat Immunol 2006 (Salmonella Infections) : Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella infected macrophages
Li et al., J Immunol 2008 (Inflammation) : In this study we show that, in human and mouse macrophages, alum induced secretion of IL-1beta , IL-18, and IL-33 is mediated by the NLR ( nucleotide binding domain leucine-rich repeat containing ) protein NLRP3 and its adaptor ASC, but not by NLRC4
Franchi et al., Immunol Rev 2009 (Autoimmune Diseases...) : In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4 , Nlpr1, and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as interleukin-1 beta