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CDK4 — JUN
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shen et al., Cell Biol Int 2008
(MAP Kinase Signaling System...) :
Activator protein-1 (AP-1) was
responsible for the decrease of
CDK4 expression level, but not that of cyclin D1
Vanden Bush et al., PloS one 2011
:
Additionally, the activity of
AP-1 , a ubiquitous transcription factor containing phosphorylated c-Jun as a subunit, was
inhibited by abrogating
CDK4 ... Surprisingly, the
regulation of
c-Jun phosphorylation by
CDK4 occurred in non dividing cells, indicating that this pathway is utilized for cell functions that are independent of proliferation
Jalili et al., J Natl Cancer Inst 2012
(MAP Kinase Signaling System...) :
Using a dominant negative approach, in vitro cell proliferation assays, western blots, and flow cytometry showed that MAPK signaling via BRAF ( V600E ) promotes melanoma cell proliferation at G1 through
AP-1 mediated negative regulation of the INK4 family member,
cyclin dependent kinase inhibitor 2C ( CDKN2C ), and the CIP/KIP family member, cyclin dependent kinase inhibitor 1A ( CDKN1A )