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ICOSLG — IRF6
Text-mined interactions from Literome
Taylor et al., Blood 2005
(Graft vs Host Disease) :
ICOS ligand , a B7 family member, is constitutively expressed on B cells, macrophages, and dendritic cells and is
up-regulated on antigen presenting cells (APCs) and some nonlymphoid tissues by tumor necrosis factor alpha (TNFalpha) or
lipopolysaccharide (LPS)
Zhou et al., Eur J Immunol 2005
:
In this report, we demonstrate that
LPS induced
up-regulation of B7-related protein 1
(B7RP-1) , a ligand for ICOS, is dependent primarily upon the MyD88 dependent signaling pathway ... Hence,
LPS induces significantly higher
B7RP-1 expression on TRIF- or TRAM-deficient mouse peritoneal macrophages and on TRIF-deficient mouse splenic B cells as compared to wild-type cells
Thoeni et al., J Immunol 2005
:
Checking for a possible influence on LPS induced dendritic cell maturation, we found that tetrahydro-4-aminobiopterin down-regulated MHC class II expression and counteracted
LPS induced down-regulation of
ICOS ligand , while expression of CD40, CD86, CD80, B7-H1, and B7-DC remained unchanged