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P2RY1 — PRKAR2B
Text-mined interactions from Literome
Guerra et al., Pflugers Arch 2004
:
These data suggest that the X laevis
P2Y1 receptor in A6 cells can
increase both
cAMP/PKA and Ca2+/PKC intracellular levels and that the PKC pathway is involved in CFTR activation via potentiation of the PKA pathway
Akimova et al., J Physiol 2005
:
The rank order of potency ( 2MeSATP > ATP > ADP > > UTP ) indicates that
P 2Y1 rather than P 2Y2 receptors
contribute to
PKA and I ( SC ) activation ... Viewed collectively, these data show that Cl- secretion in C7-MDCK monolayers treated with basolateral ATP is triggered by
P 2Y1 receptors and is
mediated by subsequent [ Ca2+ ] i-independent activation of PLA2 and
PKA