Kobayashi et al., Biochem J 1999
:
Our results are consistent with a model in which activation of SGK by IGF-1 or hydrogen peroxide is initiated by a PtdIns ( 3,4, 5 ) P3-dependent activation of PDK2 , which phosphorylates Ser422
Wang et al., Biochim Biophys Acta 2012
(Ion Channel Gating) :
Western blot analysis demonstrated that IGF-1 significantly increased the phosphorylation of phospholipid dependent kinase ( PDK ) at serine residue 241 ( Ser ( 241 ) ) and AKT at Ser ( 473 ) in the isolated medullary TAL ... Moreover, inhibition of PI3K with LY294002 abolished the effect of IGF-1 on the phosphorylation of PDK and AKT