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IL10 — TYK2
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3,
Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Petit-Bertron et al., J Leukoc Biol 2003
:
Tyk2 and signal transducer and activator of transcription 3 ( STAT3 ) phosphorylation and suppressor of cytokine signaling 3 ( SOCS3 ) expression were
induced by
IL-10 in both conditions, but a longer activation and/or expression were observed in adherent monocytes
Stearns et al., Oncogene 2003
(Prostatic Neoplasms) :
IL-10E1 signaling
involves tyrosine phosphorylation of the IL-10R JAK1 ( Janus kinase ) and
TYK2 ( tyrosine kinase) receptor kinases and tyrosine phosphorylation of two tyrosine moieties ( Y57 and Y62 ) of a LIM domain of the IL-10E1 protein
Shaw et al., J Immunol 2006
(Genetic Predisposition to Disease...) :
Tyk2 negatively
regulates adaptive Th1 immunity by mediating
IL-10 signaling and promoting IFN-gamma dependent IL-10 reactivation
Valencia-Pacheco et al., Scand J Rheumatol 2006
(Lupus Erythematosus, Systemic) :
In addition, variable levels of Jak-1,
Tyk-2 , Stat-1, and Stat-3 activation were
induced by
IL-10 in PBMCs from SLE patients and controls, with no significant differences in protein phosphorylation or kinetics of activation
Horie et al., Microbiol Immunol 2007
(Burkitt Lymphoma) :
Exogenous
IL-10 lead rapidly to phosphorylation of Jak1 and
Tyk2 as transducers of signals of IL-10, and promoted growth of Akata cells in a dose dependent manner
Sanda et al., Cancer Discov 2013
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
Activation of this TYK2-STAT1 pathway in T-ALL cell lines occurs by gain-of-function
TYK2 mutations or
activation of
interleukin (IL)-10 receptor signaling, and this pathway mediates T-ALL cell survival through upregulation of the antiapoptotic protein BCL2