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CD28 — CHUK
Text-mined interactions from Literome
Khoshnan et al., J Immunol 1999
:
We demonstrate that stimulation of primary human CD4+ T cells by
CD3/CD28 activates two distinct endogenous IKK complexes, a heterodimeric
IKK alpha/beta and a homodimeric IKK beta complex ... We demonstrate that stimulation of primary human CD4+ T cells by
CD3/CD28 activates two distinct endogenous
IKK complexes, a heterodimeric IKK alpha/beta and a homodimeric IKK beta complex
Khoshnan et al., J Immunol 2000
:
The physical association of protein kinase C theta with a lipid raft associated inhibitor of kappa B factor kinase
(IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and
CD28
Dienz et al., J Immunol 2003
:
In contrast, replenishment of SLP-76 or PLCgamma1 expression restored
CD3/CD28 induced
IkappaB kinase (IKK) activity as well as NF-kappaB DNA binding and transactivation
Perchonock et al., Mol Cell Biol 2006
(Splenomegaly) :
While
TCR/CD28 mediated activations of phosphotyrosine induction, extracellular signal regulated kinase 1/2, Jun N-terminal protein kinase,
IkappaB kinase alpha/beta , and Akt were unaltered, constitutive activation of p38 mitogen activated protein kinase and its upstream regulators MKK3/6 were observed for ALX-deficient splenocytes
Düwel et al., J Immunol 2009
:
However, proteasomal inhibition impairs A20 degradation and impedes
TCR/CD28 induced
IKK activation