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CDKN1A — MEOX2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CDKN1A
→
MEOX2
(increases, CDKN1A Activity)
Evidence: Gax strongly inhibited HUVEC proliferation and mitogen-stimulated 3H-thymidine uptake. p21 expression in HUVECs transduced with Gax was increased up to 5-fold as measured by Northern blot, and p21 promoter activity was activated by 4- to 5-fold. Tube formation on Matrigel was strongly inhibited by Gax expression
Text-mined interactions from Literome
Witzenbichler et al., J Clin Invest 1999
:
Previous investigations demonstrate that
Gax may
regulate VSMC proliferation by upregulating the cyclin dependent kinase (cdk) inhibitor
p21
Chen et al., J Biol Chem 2007
:
The homeobox gene
GAX activates
p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences ... The homeobox gene
GAX inhibits angiogenesis and
induces p21 ( WAF1/CIP1 ) expression in vascular ECs ... To elucidate the mechanism through which
GAX activates
p21 ( WAF1/CIP1 ) expression, we constructed GAX cDNAs with deletions of the N-terminal domain, the homeodomain, or the C-terminal domain and then assessed these constructs for their ability to activate p21 ( WAF1/CIP1 ) ... There was an absolute requirement for the homeodomain, whereas deleting the C-terminal domain decreased but did not abolish
transactivation of the
p21 ( WAF1/CIP1 ) promoter by
GAX ... We conclude that
GAX activates
p21 ( WAF1/CIP1 ) through multiple upstream AT-rich sequences
Valcourt et al., Mol Oncol 2007
:
Moreover, ectopic
Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene
p21 ... Transcriptional
induction of
p21 by
Meox2 required a distal region of the p21 promoter that spans the p53 binding site
Douville et al., PloS one 2011
:
The homeodomain transcription factor
MEOX2 is an important regulator of vascular cell proliferation and is a direct transcriptional
activator of both
p21 ( CIP1/WAF1 ) and p16(INK4a)
Smith et al., Genes Dev 1997
(Carotid Artery Injuries) :
Gax overexpression also
led to an association of
p21 with cdk2 complexes and a decrease in cdk2 activity