Helps et al., Biochem J 2000
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Nek2 activity increases with autophosphorylation and addition of phosphatase inhibitors and decreases in the presence of PP1 Mi et al., Cancer Res 2007
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Ionizing radiation inhibited Nek2 activity, and this response was dependent on ATM and on PP1 binding to Nek2 and coincident with Thr ( 320 ) dephosphorylation of PP1