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BLNK — PLCG2

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: BLNK/LCP2 → PLCG2 (protein-protein, binding/association)
• KEGG B cell receptor signaling pathway: PLCG2 → BLNK (protein-protein, binding/association)
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → CD72/SHP1 complex (CD72-PTPN6) (modification, collaborate)
  Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → SHP1 (PTPN6) (modification, collaborate) Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → CD72/SHP1 complex (CD72-PTPN6) (modification, collaborate)
  Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → SHP1 (PTPN6) (modification, collaborate) Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: SAB (SH3BP5) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, inhibits)
  Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → PLCgamma2 (PLCG2) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
  Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → Btk (BTK) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: PLCgamma2 (PLCG2) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
  Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → CD72 (CD72) (modification, collaborate) Fusaki et al., Eur J Immunol 2000
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  Fusaki et al., Eur J Immunol 2000
• NCI Pathway Database BCR signaling pathway: CD72 (CD72) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  Fusaki et al., Eur J Immunol 2000
• NCI Pathway Database Class I PI3K signaling events: None → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
  Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, activates) Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → None (modification, activates) Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BCR signaling pathway: SHIP (INPP5D) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, inhibits)
  
• NCI Pathway Database BCR signaling pathway: None → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, activates)
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → None (modification, activates)
• Reactome Reaction: PLCG2 → BLNK (indirect_complex) Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PLCG2 — BLNK (physical association, affinity chromatography technology) Oellerich et al., EMBO J 2011
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Janssen et al., Nat Immunol 2003*
• IRef Hprd Interaction: BLNK — PLCG2 (in vivo) Tan et al., J Biol Chem 2001*
• IRef Intact Interaction: Complex of MAP2K4-BLNK-CD2AP-DOK3-GRB2-PLCG2 (association, anti bait coimmunoprecipitation) Oellerich et al., EMBO J 2011
• IRef Ophid Interaction: PLCG2 — BLNK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yasuda et al., J Exp Med 2000 : As a consequence of the interaction between Cbl and BLNK , the BCR induced recruitment of PLC-gamma2 to BLNK and the subsequent PLC-gamma2 tyrosine phosphorylation were inhibited
Tzeng et al., Protein Sci 2000 (Agammaglobulinemia) : Recently, the B-cell linker protein (BLNK) was found to interact with the SH2 domain of Btk, and this association is required for the activation of phospholipase C-gamma
Al-Alwan et al., J Immunol 2010 : In mouse primary B cells, Bam32 was required for efficient activation of the GTPase Rac1 and downstream signaling to JNK, but not activation of BLNK , phospholipase C gamma2 , or calcium responses