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IFNG — SOAT1

Text-mined interactions from Literome

Yamaoka et al., J Interferon Cytokine Res 1999 : IL-10 inhibited IFN-gamma induced STAT activation without newly synthesized protein ... We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma induced STAT activation
Li et al., Oncogene 1999 : Here we show that expression of the ` malignant ' HPV-18 E6 in human HT1080 cells results in inhibition of Jak-STAT activation in response to IFN-alpha but not IFN-gamma
Takahashi et al., Biochem J 1999 : Interferon-gamma dependent stimulation of human involucrin gene expression : STAT1 ( signal transduction and activators of transcription 1 ) protein activates involucrin promoter activity
Gollob et al., J Immunol 2000 (Immunologic Deficiency Syndromes...) : This impairment of STAT activation was specific for IL-12, as STAT activation by IL-2, IL-15, and IFN-gamma was unaffected
Cottet et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1) : SOCS-1 protein prevents Janus Kinase/STAT dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma
Maródi et al., Clin Exp Immunol 2001 : However, STAT-1 phosphorylation in response to IFN-gamma was significantly decreased in neonatal monocytes ( P < 0.05 ) and MDM ( P < 0.01 ) compared to adult cells ( n > 5 for each )
Bovolenta et al., Blood 2002 (Leukemia, Erythroblastic, Acute) : Neutralization experiments indicated that GM-CSF and IFN-gamma , but not SCF, were responsible for HTLV-2 induced STAT activation, whereas anti-GM-CSF antibodies greatly inhibited TF-1 cell proliferation
Sehgal et al., J Biol Chem 2002 : Methyl-beta-cyclodextrin, which sequesters cholesterol and disrupts plasma membrane rafts, markedly inhibited IL-6- and IFN-gamma induced STAT signaling
Andrejeva et al., J Virol 2002 : In contrast, STAT2 was absent from 2f/PIV2-V cells, and IFN-alpha/beta but not IFN-gamma signaling was blocked in these cells
Ahmed et al., J Leukoc Biol 2002 (MAP Kinase Signaling System) : Inhibition was specific for IL-6, as induction of STAT activation by IFN-gamma , IFN-alpha, and vanadate was not inhibited
Jenab et al., Neuro Endocrinol Lett 2002 (Glioma) : The effects of interleukin-6, leukemia inhibitory factor and interferon-gamma on STAT DNA binding and c-fos mRNA levels in cortical astrocytes and C6 glioma cells
Maródi et al., Acta Paediatr Suppl 2002 : However, STAT-1 phosphorylation in response to IFN-gamma was significantly decreased in neonatal monocytes ( p < 0.05 ) and macrophages ( p < 0.01 ) compared with adult cells
Hu et al., J Immunol 2003 : We investigated whether GCs could also block activation of Janus kinase-STAT signaling by IFN-gamma , a potent proinflammatory cytokine
Battle et al., Blood 2003 (Leukemia, Lymphocytic, Chronic, B-Cell) : However, STAT1 activation by IFN gamma stimulation alone was not sufficient to induce differentiation
Hong et al., Biochem Biophys Res Commun 2003 (Amyloidosis...) : AG490, which is a blocker of IFN-gamma induced STAT signaling, decreased IFN-gamma induced BACE protein expression and sAPPbeta production in a dose dependent manner
Weber et al., Am J Physiol Endocrinol Metab 2004 : In addition, these ligands impair IL-1 induced NF-kappaB and MAPK as well as IFN-gamma stimulated signal transducer and activator of transcription ( STAT ) 1 activation in beta-cells
Imai et al., FEMS Immunol Med Microbiol 2003 : Mycobacterium bovis bacillus Calmette-Guérin infection promotes SOCS induction and inhibits IFN-gamma stimulated JAK/STAT signaling in J774 macrophages
Powell et al., Clin Dev Immunol 2004 : We determined that the marked synergy between LPS and IFN-gamma on MIG mRNA expression in mouse macrophages is a result of LPS induced NF-kappaB and IFN-gamma induced STAT
Zoumpoulidou et al., Mol Endocrinol 2004 : In this study, we report that differentiating human endometrial stromal cells ( ESCs ) acquire resistance to interferon-gamma (IFNgamma) dependent signal transducers and activators of transcription ( STAT ) 1 signaling, although phosphorylation, nuclear translocation, and binding of STAT1 to DNA, are unaffected
Jeon et al., Biochem Biophys Res Commun 2005 : Nordihydroguaiaretic acid inhibits IFN-gamma induced STAT tyrosine phosphorylation in rat brain astrocytes
Choi et al., Biochem Biophys Res Commun 2005 (Inflammation) : Anti-inflammatory roles of retinoic acid in rat brain astrocytes : Suppression of interferon-gamma induced JAK/STAT phosphorylation ... Both RA isoforms also reduced IFN-gamma induced activation of signal transducers and activators of transcription ( STAT ) 1, STAT3 , Janus kinase (JAK)1, and JAK2
Ji et al., Rheumatology (Oxford) 2005 : Inhibition was not specific for IL-10, as induction of STAT activation by IFN-gamma and IL-6 was also inhibited by 15d-PGJ2
Steiner et al., J Cell Sci 2006 (Lung Neoplasms) : Summarizing, we identify MVP as an IFN-gamma-responsive gene interfering with IFN-gamma activated JAK/STAT signals
Brzózka et al., J Virol 2006 : We here show that RV P in addition is responsible for preventing IFN-alpha/beta- and IFN-gamma stimulated JAK-STAT signaling in RV-infected cells by the retention of activated STATs in the cytoplasm
Berenson et al., J Immunol 2006 : However, in differentiated Th1 cells, IFN-alpha can induce transient, but not sustained, STAT4 phosphorylation and, in synergy with IL-18, can induce transient, but not sustained, IFN-gamma production in Th1 cells, in contrast to the sustained actions of IL-12
Wormald et al., BMC genomics 2006 : In response to IFN-gamma , STAT1 bound proximally to regions of the genome that exhibit regulated transcriptional activity
Vidy et al., J Virol 2007 : Rabies virus P protein inhibits alpha interferon ( IFN-alpha ) - and IFN-gamma stimulated Jak-STAT signaling by retaining phosphorylated STAT1 in the cytoplasm
Dong et al., Lupus 2007 (Lupus Nephritis) : In MRL/lpr mesangial cells, both IFN-alpha and IFN-gamma rapidly induced the phosphorylation of STAT in vitro
Park et al., Mol Immunol 2007 (MAP Kinase Signaling System) : We have shown previously that TGF-beta1 inhibits Th1 development by inhibiting IFN-gamma 's induction of T-bet and other Th1 differentiation genes, and that TGF-beta1 inhibits receptor-proximal IFN-gamma-Jak-Stat signaling responses
Luquin et al., Antiviral Res 2007 : Our results show that IFN-alpha mediated STAT activation ( but not IFN-gamma stimulated STAT phosphorylation ) is blocked in Huh7 cell line containing the genomic replicon, while this is not observed in cells with the subgenomic replicon
Liu et al., J Immunol 2007 : Activation of NF-kappaB, STAT6 , and STAT1 was induced in eosinophils by TNF-alpha, IL-4, and IFN-gamma , respectively
Sonobe et al., Biochem Biophys Res Commun 2008 : Additionally, microglia expressed a functional receptor for IL-23, as IL-23 enhanced the Interferon (IFN)-gamma induced signal transducer and activator of transcription ( STAT ) 1 phosphorylation and chemokine production
Watling et al., Proc Natl Acad Sci U S A 2008 (Neoplasms) : JAK/STAT signaling is not, however, sufficient for a full IFN-gamma response
Whiteman et al., Journal of inflammation (London, England) 2008 : This differential effect on HRV-14 receptor isoforms appears to be related to a combination of decreased IFN-gamma induced JAK-STAT signalling and proteolytic receptor cleavage of the membranous form in IFN-gamma biased HRV-14 infected cells
Strbo et al., AIDS 2008 (Chronic Disease...) : The effects of IL-21 on perforin expression, proliferation, degranulation, interferon (IFN)-gamma production, cytotoxicity and induction of STAT phosphorylation in NK cells were determined in vitro
Gira et al., J Invest Dermatol 2009 (Anoxia) : Iron chelators and hypoxia mimetics inhibit IFNgamma mediated Jak-STAT signaling
Schaefer et al., Mol Immunol 2009 : Finally, LPS induced activity of the trimeric Stat-motif in front of the luciferase reporter was suppressed by IFNgamma
Kar et al., Eur J Immunol 2009 (Disease Models, Animal...) : DNA binding as well as silencing experiments revealed the requirement of IFN-gamma mediated JAK-STAT activation even though cystatin did not modulate this signaling cascade by itself
Koelsche et al., Mol Immunol 2009 : Altering the subcellular localization of SOCS1 by mutating clusters of arginine residues within the NLS did not affect the inhibition of interferon mediated STAT1 tyrosine-phosphorylation, but surprisingly led to impaired inhibitory activity of STAT mediated reporter gene induction and IFN-gamma induced CD54 regulation
Valmas et al., PLoS Pathog 2010 (Hemorrhagic Fever, Ebola...) : MARV infection is now demonstrated to inhibit not only IFNalpha/beta but also IFNgamma induced STAT phosphorylation and to inhibit the IFNalpha/beta and IFNgamma induced tyrosine phosphorylation of upstream Janus ( Jak ) family kinases ... Global loss of STAT and Jak tyrosine phosphorylation in response to both IFNalpha/beta and IFNgamma is reminiscent of the phenotype seen in Jak1-null cells
Shuai et al., Nature 1993 : Interferon-alpha activates both Stat91 ( M ( r ) 91,000 ; ref. 1 ) and Stat113 ( M ( r ) 113,000 ; ref. 2 ) whereas IFN-gamma activates only Stat91 ( refs 3, 4 )
Lamb et al., Nucleic Acids Res 1995 : STAT protein complexes activated by interferon-gamma and gp130 signaling molecules differ in their sequence preferences and transcriptional induction properties
Tourkine et al., J Biol Chem 1995 : Activation of STAT factors by prolactin, interferon-gamma , growth hormones, and a tyrosine phosphatase inhibitor in rabbit primary mammary epithelial cells
Seidel et al., Proc Natl Acad Sci U S A 1995 (Carcinoma, Hepatocellular...) : We have systematically examined the effects of the spacing between the TT and AA core half sites on the binding of the STAT complexes activated by IFN-gamma , interleukin (IL) 6, granulocyte-macrophage colony stimulating factor, and IL-4
Evans et al., J Bone Miner Res 1996 (Osteosarcoma) : Interferon gamma rapidly induced STAT binding in SaOS2 cells, unlike PTH
Will et al., J Immunol 1996 (Rhabdoviridae Infections) : Intracellular murine IFN-gamma mediates virus resistance, expression of oligoadenylate synthetase, and activation of STAT transcription factors
Kohlhuber et al., Mol Cell Biol 1997 : Conversely, a JAK1-JAK2 chimera with the amino-terminal domains of JAK1 linked to the pseudokinase and kinase domains of JAK2 is capable of reconstituting JAK-STAT signalling in response to IFN-alpha and -gamma in mutant U4C cells lacking JAK1
Illa et al., Am J Pathol 1997 (Dermatomyositis...) : In vitro, STAT1 was stimulated by interferon-gamma but not by the other molecules studied
Lehtonen et al., J Immunol 1997 : We have characterized the expression of STAT and IFN regulatory factor ( IRF ) family transcription factors in primary human blood mononuclear cells and macrophages in response to IFN-alpha and IFN-gamma stimulation
Chin et al., Mol Cell Biol 1997 : We further demonstrated that both EGF and IFN-gamma induced caspase 1 ( interleukin-1beta converting enzyme [ ICE ] ) gene expression in a STAT dependent manner
Ohmori et al., J Immunol 1997 : The effects of IFN-gamma and IL-4 on transcription of a reporter gene under control of a 1.3-kb fragment from the IRF-1 gene promoter or the STAT binding element (SBE) from this gene in the context of a heterologous promoter are similar to their effects on the endogenous IRF-1 gene
Lee et al., Infect Immun 1998 : These results suggest that E. chaffeensis blocks IFN-gamma induced tyrosine phosphorylation of Jak and Stat through raising PKA activity in THP-1 cells, which may be an important survival mechanism of ehrlichiae within the host cell
Wang et al., Ann Surg Oncol 1998 (Carcinoid Tumor...) : We have shown that both IFN-alpha and IFN-gamma can induce Stat protein binding ( particularly Stat3 and Stat5 ) to their cognate DNA consensus sites and increase Stat protein steady state levels in BON cells