◀ Back to IFNG

IFNG — VCAM1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VCAM1 → IFNG (increases)
  Evidence: Members of the immunoglobulin superfamily mediate heterophilic cell-cell adhesion. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are expressed on quiescent endothelium, but are upregulated after stimulation with TNF-a, IL-1 or interferon-g (IFN-g) (24).

Text-mined interactions from Literome

Spoelstra et al., Eur Respir J 1999 : Interferon-gamma and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts ... IFNgamma ( OC 2 U x mL(-1) ) increased only ICAM-1 expression and IL-4 ( OC 5 ng x mL(-1) ) increased only VCAM-1 expression, whereas IL-5 ( 20 ng x mL(-1) ) and TGFbeta ( 10 ng x mL(-1) ) did not influence ICAM-1 or VCAM-1 expression ... It is concluded that the Helper-1T-cell, type cytokine interferon gamma and the Helper-2 T-cell type cytokine interleukin-4 differentially regulate intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on human lung fibroblasts
De Caterina et al., Arterioscler Thromb Vasc Biol 2001 : Although IFN-gamma induced major histocompatibility complex class II antigen expression and although a high concentration of IL-1alpha ( 10 ng/mL ) induced leukocyte adhesion and VCAM-1 expression, neither IFN-gamma nor LC IL-1alpha was able to induce VCAM-1 expression or leukocyte adhesion
Murakami et al., Microvasc Res 2001 : TNF-alpha induced the expression of VCAM-1 on HUVEC and GEC, but not MvE, while IFN-gamma induced VCAM-1 expression only on HUVEC
Penfold et al., Invest Ophthalmol Vis Sci 2002 : Expression of VCAM1 was induced after stimulation with both IFNgamma and TNFalpha, whereas expression of MHC-II was induced only by stimulation with IFNgamma
Vachula et al., Invasion Metastasis 1992 : In addition, interferon-gamma upregulates ICAM-1, and IL-4 can induce VCAM-1
Teo et al., The AAPS journal 2005 (Multiple Myeloma...) : They induce an IL-2 mediated primary T cell proliferation with a concomitant increase in IFN-gamma production and decrease the density of TNF-alpha induced cell surface adhesion molecules ICAM-1, VCAM-1 , and E-selectin on human umbilical vein endothelial cells
Hosokawa et al., Clin Exp Immunol 2006 : Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma enhanced both ICAM-1 and VCAM-1 expression on HGF
Wang et al., J Interferon Cytokine Res 2007 (Toxoplasmosis) : Importance of IFN-gamma mediated expression of endothelial VCAM-1 on recruitment of CD8+ T cells into the brain during chronic infection with Toxoplasma gondii ... These results indicate that IFN-gamma induced expression of endothelial VCAM-1 and its binding to alpha4beta1 integrin on CD8 ( + ) T cells is important for recruitment of the T cells into the brain during the chronic stage of T. gondii infection, although LFA-1/ICAM-1 interaction may also be involved in this process
Defrère et al., Gynecol Obstet Invest 2008 : Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in human endometrial stromal and epithelial cells is regulated by interferon-gamma but not iron
Couffinhal et al., Circ Res 1994 : Interferon-gamma induced a weak increase in VCAM-1 mRNA expression, with no synergistic effect on the stimulation by TNF-alpha
Watanabe et al., Biochem Biophys Res Commun 1995 : Tumor necrosis factor alpha and interleukin-1 beta but not interferon gamma induce vascular cell adhesion molecule-1 expression on primary cultured murine hepatocytes ... TNF alpha and IL-1 beta but not IFN gamma or IL-6 induced VCAM-1 expression on primary cultured murine hepatocytes in a dose- and a time dependent fashion
Groves et al., J Am Acad Dermatol 1993 (Dermatitis, Allergic Contact...) : IFN-gamma led to marked upregulation of endothelial and dermal dendritic cell VCAM-1
Schwachula et al., Immunobiology 1994 : The upregulation of ICAM-1 by IL-1 alpha, TNF-alpha, and IFN-gamma appeared similar, whereas the induction of VCAM-1 by IL-1 alpha, IL-4, TNF-alpha, and IFN-gamma showed differences between the three cell types
Shin et al., J Biol Chem 1996 : Nuclear run-on assays and transfection studies using various VCAM-1 promoter constructs linked to the chloramphenicol acetyl-transferase reporter gene showed that .NO repressed IFN-gamma induced VCAM-1 gene transcription, in part, through inhibition of nuclear factor-kappa B (NF-kappa B) ... These findings suggest that the induction of ICAM-1 and VCAM-1 expression requires NF-kappa B activation and that .NO attenuates IFN-gamma induced VCAM-1 expression primarily by inhibiting basal constitutive NF-kappa B activity in SMC
Scholz et al., Transplantation 1996 (Cytomegalovirus Infections) : Whereas oxidative stress alone did not modulate any surface molecule expression, the IFN-gamma mediated expression of HLA-ABC and HLA-DR and the IL-1 mediated expression of ICAM-1, but not of ELAM-1 and VCAM-1 ( IL-1 + TNF-alpha ), was amplified
Castro et al., Eur J Cell Biol 1996 : They express ICAM-1, VCAM-1 and CD40 both constitutively and in inducible forms and are induced by IFN-gamma to express major histocompatibility complex class II antigens
Okada et al., Ann Med Interne (Paris) 1997 : IFN gamma did not cause any changes in the expression of ELAM-1, VCAM-1 , and ICAM-1
Shen et al., J Virol 1997 : TNF-alpha significantly enhanced WNV induced increases in E-selectin, P-selectin, ICAM-1, and VCAM-1 expression, while IFN-gamma enhanced WNV induced ICAM-1 expression
Tan et al., J Immunol 1998 (Encephalomyelitis, Autoimmune, Experimental) : IFN-gamma activation up-regulated ICAM-1, VCAM-1 , MHC class II, invariant chain, H2-M, CD40, and B7-1 as determined by FACS and/or RT-PCR analyses
Peng et al., J Immunol 1998 (Inflammation) : Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma
Chuluyan et al., Life Sci 1998 (Neuroblastoma) : VCAM-1 expression on SK-N-SH was induced by IL-1alpha and TNF alpha and IFN gamma synergized with TNF alpha in this respect on both NB cell lines