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MAP2K1 — MMP3

Text-mined interactions from Literome

Reunanen et al., J Biol Chem 2002 : Activation of endogenous ERK1/2 by adenovirus mediated transfer of constitutively active MEK1 resulted in potent induction of MMP-1 and MMP-3 expression
Miyata et al., Mol Cancer Ther 2004 (Neoplasm Invasiveness) : Therefore, these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms : ( 1 ) the inhibition of MEK1/2 activity is involved in the suppression of MMP expression and ( 2 ) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression
Alexander et al., Cell Physiol Biochem 2006 (Arthritis, Rheumatoid...) : Examination of signal transduction pathways participating in the regulation of leflunomideinduced MMPs expression showed that the mechanism underlying activation of MMP-1 is in part p38- and activation of MMP-3 was MEK1/2- dependent
Kajanne et al., J Cell Physiol 2007 : Conversely, expression of a constitutively active Mek1 can induce MMP-3 expression independently of upstream signals
Goda et al., J Dent Res 2008 (Periodontal Diseases) : We demonstrated that MMP-3 was produced from MG63 cells in response to Emdogain in a MEK1/2 dependent manner