Iida et al., FEBS Lett 2002
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Using a ligand of PPAR gamma, troglitazone or pioglitazone, we have shown that the expression of two genes involved in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA) synthase and HMG-CoA reductase , were increased by activation of PPAR gamma through a PPAR response element (PPRE) in THP-1 macrophages
Lee et al., Dig Dis Sci 2010
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HMG-CoA reductase inhibitors ( statins ) activate expression of PPARalpha/PPARgamma and ABCA1 in cultured gallbladder epithelial cells ... Recently, HMG-CoA reductase inhibitors ( statins ) were shown to activate PPARalpha and PPARgamma in various cells but no studies of their effects in GBEC have been conducted